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Billig SCI, Schauermann JC, Rolke R, et al. Quantitative sensory testing predicts histological small fiber neuropathy in postural tachycardia syndrome. Neurol Clin Pract. 2020;10(5):428-434doi: 10.1212/CPJ.0000000000000770.
Billig, S. C. I., Schauermann, J. C., Rolke, R., Katona, I., Schulz, J. B., & Maier, A. (2020). Quantitative sensory testing predicts histological small fiber neuropathy in postural tachycardia syndrome. Neurology. Clinical practice, 10(5), 428-434. https://doi.org/10.1212/CPJ.0000000000000770
Billig, Sophia C I, et al. "Quantitative sensory testing predicts histological small fiber neuropathy in postural tachycardia syndrome." Neurology. Clinical practice vol. 10,5 (2020): 428-434. doi: https://doi.org/10.1212/CPJ.0000000000000770
Billig SCI, Schauermann JC, Rolke R, Katona I, Schulz JB, Maier A. Quantitative sensory testing predicts histological small fiber neuropathy in postural tachycardia syndrome. Neurol Clin Pract. 2020 Oct;10(5):428-434. doi: 10.1212/CPJ.0000000000000770. PMID: 33299671; PMCID: PMC7717634.
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Neurol Clin Pract. 2020 Oct;10(5):428-434. doi: 10.1212/CPJ.0000000000000770.

Quantitative sensory testing predicts histological small fiber neuropathy in postural tachycardia syndrome.

Neurology. Clinical practice

Sophia C I Billig, Joana C Schauermann, Roman Rolke, Istvan Katona, Jörg B Schulz, Andrea Maier

Affiliations

  1. Department of Neurology (SCIB, JCS, AM, JBS), Department of Neuropathology (IK), Department of Palliative Care (RR), RWTH Aachen University; Research Training Group 2416 MultiSenses-MultiScales (JBS), Aachen; and Forschungszentrum Jülich GmbH (JBS), JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Jülich, Germany.

PMID: 33299671 PMCID: PMC7717634 DOI: 10.1212/CPJ.0000000000000770

Abstract

BACKGROUND: Retrospective investigation of the somatosensory profile and prediction of histologic small fiber neuropathy (SFN) in postural orthostatic tachycardia syndrome (POTS) was performed using quantitative sensory testing (QST) as a standardized noninvasive test.

METHODS: In this investigation, full data sets from 30 patients (age: 34.03 ± 10.82 years, n = 6 males), including results of autonomic function testing, norepinephrine values, skin biopsy, and QST, were retrospectively analyzed. The QST data were compared with healthy controls (HCs) (age: 34.20 ± 10.5 years, n = 6 males,

RESULTS: The evaluation of all QST parameters in POTS compared with HCs yielded differences in all thermal parameters (cold detection threshold:

CONCLUSION: These results suggest that a non-region-specific SFN in POTS compared with controls can be detected by noninvasive QST that predicts histologic small fiber pathology.

© 2019 American Academy of Neurology.

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