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Kenchappa RS, Mistriotis P, Wisniewski E, et al. Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma. iScience. 2020;23(12):101802doi: 10.1016/j.isci.2020.101802.
Kenchappa, R. S., Mistriotis, P., Wisniewski, E., Bhattacharya, S., Kulkarni, T., West, R., Luu, A., Conlon, M., Heimsath, E., Crish, J. F., Picariello, H. S., Dovas, A., Zarco, N., Lara-Velazquez, M., Quiñones-Hinojosa, A., Hammer, J. A., Mukhopadhyay, D., Cheney, R. E., Konstantopoulos, K., Canoll, P., & Rosenfeld, S. S. (2020). Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma. iScience, 23(12), 101802. https://doi.org/10.1016/j.isci.2020.101802
Kenchappa, Rajappa S, et al. "Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma." iScience vol. 23,12 (2020): 101802. doi: https://doi.org/10.1016/j.isci.2020.101802
Kenchappa RS, Mistriotis P, Wisniewski E, Bhattacharya S, Kulkarni T, West R, Luu A, Conlon M, Heimsath E, Crish JF, Picariello HS, Dovas A, Zarco N, Lara-Velazquez M, Quiñones-Hinojosa A, Hammer JA, Mukhopadhyay D, Cheney RE, Konstantopoulos K, Canoll P, Rosenfeld SS. Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma. iScience. 2020 Nov 13;23(12):101802. doi: 10.1016/j.isci.2020.101802. eCollection 2020 Dec 18. PMID: 33299973; PMCID: PMC7702012.
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iScience. 2020 Nov 13;23(12):101802. doi: 10.1016/j.isci.2020.101802. eCollection 2020 Dec 18.

Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma.

iScience

Rajappa S Kenchappa, Panagiotis Mistriotis, Emily Wisniewski, Santanu Bhattacharya, Tanmay Kulkarni, Rita West, Amanda Luu, Meghan Conlon, Ernest Heimsath, James F Crish, Hannah S Picariello, Athanassios Dovas, Natanael Zarco, Montserrat Lara-Velazquez, Alfredo Quiñones-Hinojosa, John A Hammer, Debrabrata Mukhopadhyay, Richard E Cheney, Konstantinos Konstantopoulos, Peter Canoll, Steven S Rosenfeld

Affiliations

  1. Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
  2. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  3. Departments of Biochemistry and Molecular Biology and Physiology and Biomedical Engineering, Mayo Clinic, Jacksonville, FL 32224, USA.
  4. Department of Cell Biology and Physiology, and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  5. Department of Cancer Biology, Lerner Research Institute, Cleveland, OH 44106, USA.
  6. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
  7. Department of Neurosurgery, Mayo Clinic, Jacksonville, FL 32224, USA.
  8. Cell and Developmental Biology Center, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.

PMID: 33299973 PMCID: PMC7702012 DOI: 10.1016/j.isci.2020.101802

Abstract

Invasion and proliferation are defining phenotypes of cancer, and in glioblastoma blocking one stimulates the other, implying that effective therapy must inhibit both, ideally through a single target that is also dispensable for normal tissue function. The molecular motor myosin 10 meets these criteria. Myosin 10 knockout mice can survive to adulthood, implying that normal cells can compensate for its loss; its deletion impairs invasion, slows proliferation, and prolongs survival in murine models of glioblastoma. Myosin 10 deletion also enhances tumor dependency on the DNA damage and the metabolic stress responses and induces synthetic lethality when combined with inhibitors of these processes. Our results thus demonstrate that targeting myosin 10 is active against glioblastoma by itself, synergizes with other clinically available therapeutics, may have acceptable side effects in normal tissues, and has potential as a heretofore unexplored therapeutic approach for this disease.

© 2020 The Author(s).

Keywords: Cancer; Cell Biology

Conflict of interest statement

The authors declare that they have no competing interests.

References

  1. J Cell Biol. 2019 Dec 2;218(12):4093-4111 - PubMed
  2. J Biol Chem. 2012 Jul 20;287(30):24873-83 - PubMed
  3. Brain. 2011 May;134(Pt 5):1331-43 - PubMed
  4. J Biol Chem. 1997 Mar 28;272(13):8474-81 - PubMed
  5. Oncogene. 2017 Jun 29;36(26):3673-3685 - PubMed
  6. Neurology. 2008 Mar 4;70(10):779-87 - PubMed
  7. J Cell Sci. 2011 Nov 15;124(Pt 22):3733-41 - PubMed
  8. Genes Dev. 2015 Jun 15;29(12):1203-17 - PubMed
  9. Nature. 2006 Dec 7;444(7120):756-60 - PubMed
  10. Oncotarget. 2015 Apr 10;6(10):8244-54 - PubMed
  11. Trends Cancer. 2017 Mar;3(3):225-234 - PubMed
  12. J Neurosci. 2006 Jun 21;26(25):6781-90 - PubMed
  13. FASEB J. 2011 Dec;25(12):4358-68 - PubMed
  14. Cell Adh Migr. 2011 Sep-Oct;5(5):421-30 - PubMed
  15. Circ Res. 2007 Feb 16;100(3):328-41 - PubMed
  16. Cancer Cell. 2012 Jul 10;22(1):21-35 - PubMed
  17. Br J Cancer. 2014 Jul 29;111(3):539-50 - PubMed
  18. J Cell Biol. 2018 Mar 5;217(3):849-859 - PubMed
  19. Bioarchitecture. 2014;4(3):88-102 - PubMed
  20. J Cell Biol. 2008 Jul 14;182(1):77-88 - PubMed
  21. J Biol Chem. 2006 Nov 17;281(46):34870-9 - PubMed
  22. Sci Signal. 2013 Sep 17;6(293):ra82 - PubMed
  23. Cell Rep. 2015 Dec 15;13(10):2118-25 - PubMed
  24. J Clin Invest. 2014 Mar;124(3):1069-82 - PubMed
  25. J Cell Sci. 2010 Oct 15;123(Pt 20):3525-34 - PubMed
  26. Curr Opin Cell Biol. 2015 Apr;33:1-7 - PubMed
  27. Sci Rep. 2017 Dec 11;7(1):17354 - PubMed
  28. Cancer. 1989 May 15;63(10):2014-23 - PubMed
  29. Neurosurgery. 1996 Aug;39(2):235-50; discussion 250-2 - PubMed
  30. Dev Cell. 2015 Aug 10;34(3):323-37 - PubMed
  31. Nat Cell Biol. 2002 Jul;4(7):469-77 - PubMed
  32. Curr Opin Cell Biol. 2011 Oct;23(5):579-88 - PubMed
  33. Sci Transl Med. 2015 Sep 9;7(304):304ra143 - PubMed
  34. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15550-15559 - PubMed
  35. Nat Cell Biol. 2004 Jun;6(6):523-31 - PubMed
  36. PLoS One. 2013 Jul 11;8(7):e67552 - PubMed
  37. Sci Adv. 2019 Jul 24;5(7):eaaw7243 - PubMed
  38. Cell Death Differ. 2014 Feb;21(2):258-69 - PubMed
  39. Sci Adv. 2020 Jul 24;6(30):eaaz6197 - PubMed
  40. J Neurosci. 2008 Jul 2;28(27):7006-12 - PubMed
  41. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5567-72 - PubMed
  42. Cancer Res. 2004 Oct 1;64(19):7011-21 - PubMed
  43. Sci Rep. 2018 Jul 11;8(1):10449 - PubMed
  44. PLoS One. 2013 Aug 15;8(8):e72134 - PubMed
  45. Prog Neurol Surg. 2018;31:116-144 - PubMed

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