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Vanga A, Magoon S, Kowalewska J, et al. Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant. Case Rep Nephrol Dial. 2020;10(3):154-162doi: 10.1159/000510871.
Vanga, A., Magoon, S., Kowalewska, J., & Mussarat, S. (2020). Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant. Case reports in nephrology and dialysis, 10(3), 154-162. https://doi.org/10.1159/000510871
Vanga, Amaresh, et al. "Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant." Case reports in nephrology and dialysis vol. 10,3 (2020): 154-162. doi: https://doi.org/10.1159/000510871
Vanga A, Magoon S, Kowalewska J, Mussarat S. Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant. Case Rep Nephrol Dial. 2020 Nov 17;10(3):154-162. doi: 10.1159/000510871. eCollection 2020. PMID: 33363217; PMCID: PMC7747065.
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Case Rep Nephrol Dial. 2020 Nov 17;10(3):154-162. doi: 10.1159/000510871. eCollection 2020.

Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant.

Case reports in nephrology and dialysis

Amaresh Vanga, Sandeep Magoon, Jolanta Kowalewska, Saad Mussarat

Affiliations

  1. Department of Nephrology and Hypertension, Eastern Virginia Medical School, Norfolk, Virginia, USA.
  2. Department of Pathology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
  3. Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.

PMID: 33363217 PMCID: PMC7747065 DOI: 10.1159/000510871

Abstract

Fibrillary and immunotactoid glomerulonephritis are infrequent causes of primary nephrotic range proteinuria and are poorly understood. Recent significant developments include the discovery of DNA JB9 antigen in fibrillary glomerulonephritis. Here, we present a case of a middle-aged woman who presented with nephrotic range proteinuria, hematuria, and normal renal function. Renal biopsy revealed fibrils that were randomly arranged on electron microscopy. They were of small size and congo red negative similar to the ones found in fibrillary glomerulonephritis, but were also DNA JB 9 negative, and had a hollow core like in immunotactoid glomerulopathy. Though we try to classify these conditions into either immunotactoid glomerulonephropathy (ITGN) or fibrillary glomerulonephritis (FGN), there are scenarios such as this case where it does not fit into either and is probably an overlap or intermediate variant of these two conditions. Pathological features of these glomerulonephrites are discussed together with their clinical implications, treatment choices, and diagnostic importance.

Copyright © 2020 by S. Karger AG, Basel.

Keywords: Biopsy; Glomerulonephritis; Proteinuria

Conflict of interest statement

The authors have no conflicts of interest to declare

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