Display options
Cite
Petitjean M, Aussant F, Vergara A, et al. Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin. Gels. 2020;6(4)doi: 10.3390/gels6040051.
Petitjean, M., Aussant, F., Vergara, A., & Isasi, J. R. (2020). Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin. Gels (Basel, Switzerland), 6(4), . https://doi.org/10.3390/gels6040051
Petitjean, Max, et al. "Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin." Gels (Basel, Switzerland) vol. 6,4 (2020). doi: https://doi.org/10.3390/gels6040051
Petitjean M, Aussant F, Vergara A, Isasi JR. Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin. Gels. 2020 Dec 15;6(4). doi: 10.3390/gels6040051. PMID: 33333946; PMCID: PMC7768548.
Copy Download .nbib Format: NLM
Share it on

Gels. 2020 Dec 15;6(4). doi: 10.3390/gels6040051.

Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin.

Gels (Basel, Switzerland)

Max Petitjean, Florian Aussant, Ainara Vergara, José Ramón Isasi

Affiliations

  1. Department of Chemistry, University of Navarra, 31080 Pamplona, Spain.

PMID: 33333946 PMCID: PMC7768548 DOI: 10.3390/gels6040051

Abstract

The incorporation of cyclodextrins into polymeric crosslinked gels of hydrophilic nature can be useful for promoting the sorption of hydrophobic molecules and/or modulating the release of active principles. The covalent addition of these excipients to the matrix integrates their solubilizing effect that can contribute to increase the capacity of retention of hydrophobic substances. In this study, three diverse polysaccharides, chitosan, xanthan gum, and locust bean gum, were crosslinked with or without β-cyclodextrin, using citric acid in different ratios, to create hydrogel matrices. Through a green synthetic path, the efficient production of soluble and insoluble (hydrogel) networks functionalized with β-cyclodextrin was achieved by means of a solventless procedure. The characterization of their chemical composition, swelling in water, and their sorption and release behavior were also carried out in this work.

Keywords: chitosan; cyclodextrin polymers; green synthesis; hydrogels; locust bean gum; sorption; xanthan gum

References

  1. Int J Biol Macromol. 2016 Dec;93(Pt A):75-86 - PubMed
  2. Gels. 2017 Oct 19;3(4): - PubMed
  3. Gels. 2018 May 22;4(2): - PubMed
  4. Int J Biol Macromol. 2014 May;66:74-80 - PubMed
  5. Carbohydr Polym. 2013 Feb 15;92(2):1091-9 - PubMed
  6. Carbohydr Polym. 2019 Oct 1;221:94-112 - PubMed
  7. Carbohydr Polym. 2019 Feb 1;205:225-235 - PubMed
  8. Int J Pharm. 2017 Oct 15;531(2):470-479 - PubMed
  9. Biotechnol Adv. 2000 Nov 1;18(7):549-79 - PubMed
  10. J Biochem Biophys Methods. 1987 Apr;14(2):85-92 - PubMed
  11. Trends Biotechnol. 2015 Jun;33(6):362-9 - PubMed

Publication Types

Grant support