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Mouchtouri ET, Lekkas P, Delis F, et al. Sympathetic and Vagal Responses Elicited by Acute Stress in Rats. Cureus. 2020;12(11):e11602doi: 10.7759/cureus.11602.
Mouchtouri, E. T., Lekkas, P., Delis, F., Pantelakis, E., Mourouzis, I., Pantos, C., & Kolettis, T. M. (2020). Sympathetic and Vagal Responses Elicited by Acute Stress in Rats. Cureus, 12(11), e11602. https://doi.org/10.7759/cureus.11602
Mouchtouri, Eleni-Taxiarchia, et al. "Sympathetic and Vagal Responses Elicited by Acute Stress in Rats." Cureus vol. 12,11 (2020): e11602. doi: https://doi.org/10.7759/cureus.11602
Mouchtouri ET, Lekkas P, Delis F, Pantelakis E, Mourouzis I, Pantos C, Kolettis TM. Sympathetic and Vagal Responses Elicited by Acute Stress in Rats. Cureus. 2020 Nov 20;12(11):e11602. doi: 10.7759/cureus.11602. PMID: 33364122; PMCID: PMC7752793.
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Cureus. 2020 Nov 20;12(11):e11602. doi: 10.7759/cureus.11602.

Sympathetic and Vagal Responses Elicited by Acute Stress in Rats.

Cureus

Eleni-Taxiarchia Mouchtouri, Panagiotis Lekkas, Foteini Delis, Emmanouil Pantelakis, Iordanis Mourouzis, Constantinos Pantos, Theofilos M Kolettis

Affiliations

  1. Cardiology, University of Ioannina, Ioannina, GRC.
  2. Cardiology, Cardiovascular Research Institute, Ioannina, GRC.
  3. Physiology, University of Ioannina, Ioannina, GRC.
  4. Pharmacology, University of Ioannina, Ioannina, GRC.
  5. Pharmacology, National and Kapodistrian University of Athens, Athens, GRC.

PMID: 33364122 PMCID: PMC7752793 DOI: 10.7759/cureus.11602

Abstract

Introduction Acute emotional stress triggers autonomic responses that affect sympathovagal balance. However, the temporal pattern of changes in each autonomic arm during stress and recovery remains unclear. Therefore, we analyzed separately sympathetic and vagal activity, elicited by acute unpredictable stress in a rat model. Methods Continuous electrocardiographic recording was performed during (32 minutes) and after (two hours) successive use of restraint and air-jet stress in 10 rats, whereas five rats served as controls. Sympathetic and vagal indices were calculated non-invasively after heart rate variability analysis. Voluntary motion was quantified during recovery, as an index of continuing anxiety. Results The sympathetic nervous system index increased during stress and remained elevated during the initial stage of recovery. The parasympathetic nervous system index decreased immediately after the onset of stress and remained low throughout the observational period. During recovery, voluntary activity was more pronounced in the stress group than in the controls. Conclusion Successive restraint and air-jet stress in rats increased sympathetic activity and decreased vagal activity. These changes displayed only partial recovery post-stress and were accompanied by enhanced voluntary motion. Our findings may be important in the evaluation of the cardiac electrophysiologic implications of autonomic changes elicited by acute emotional stress.

Copyright © 2020, Mouchtouri et al.

Keywords: acute stress; heart rate variability; recovery; sympathetic response; vagal response

Conflict of interest statement

The authors have declared that no competing interests exist.

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