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Sugita Y, Yamamoto H, Maeda Y, et al. Influence of Aging on the Retina and Visual Motion Processing for Optokinetic Responses in Mice. Front Neurosci. 2020;14:586013doi: 10.3389/fnins.2020.586013.
Sugita, Y., Yamamoto, H., Maeda, Y., & Furukawa, T. (2020). Influence of Aging on the Retina and Visual Motion Processing for Optokinetic Responses in Mice. Frontiers in neuroscience, 14586013. https://doi.org/10.3389/fnins.2020.586013
Sugita, Yuko, et al. "Influence of Aging on the Retina and Visual Motion Processing for Optokinetic Responses in Mice." Frontiers in neuroscience vol. 14 (2020): 586013. doi: https://doi.org/10.3389/fnins.2020.586013
Sugita Y, Yamamoto H, Maeda Y, Furukawa T. Influence of Aging on the Retina and Visual Motion Processing for Optokinetic Responses in Mice. Front Neurosci. 2020 Dec 01;14:586013. doi: 10.3389/fnins.2020.586013. eCollection 2020. PMID: 33335469; PMCID: PMC7736246.
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Front Neurosci. 2020 Dec 01;14:586013. doi: 10.3389/fnins.2020.586013. eCollection 2020.

Influence of Aging on the Retina and Visual Motion Processing for Optokinetic Responses in Mice.

Frontiers in neuroscience

Yuko Sugita, Haruka Yamamoto, Yamato Maeda, Takahisa Furukawa

Affiliations

  1. Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka, Japan.

PMID: 33335469 PMCID: PMC7736246 DOI: 10.3389/fnins.2020.586013

Abstract

The decline in visual function due to normal aging impacts various aspects of our daily lives. Previous reports suggest that the aging retina exhibits mislocalization of photoreceptor terminals and reduced amplitudes of scotopic and photopic electroretinogram (ERG) responses in mice. These abnormalities are thought to contribute to age-related visual impairment; however, the extent to which visual function is impaired by aging at the organismal level is unclear. In the present study, we focus on the age-related changes of the optokinetic responses (OKRs) in visual processing. Moreover, we investigated the initial and late phases of the OKRs in young adult (2-3 months old) and aging mice (21-24 months old). The initial phase was evaluated by measuring the open-loop eye velocity of OKRs using sinusoidal grating patterns of various spatial frequencies (SFs) and moving at various temporal frequencies (TFs) for 0.5 s. The aging mice exhibited initial OKRs with a spatiotemporal frequency tuning that was slightly different from those in young adult mice. The late-phase OKRs were investigated by measuring the slow-phase velocity of the optokinetic nystagmus evoked by sinusoidal gratings of various spatiotemporal frequencies moving for 30 s. We found that optimal SF and TF in the normal aging mice are both reduced compared with those in young adult mice. In addition, we measured the OKRs of

Copyright © 2020 Sugita, Yamamoto, Maeda and Furukawa.

Keywords: aging; electroretinogram; eye movement; horizontal cells; optokinetic response; photoreceptor cells; retina; visual function

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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