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Saggese P, Sellitto A, Martinez CA, et al. Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer. Cancers (Basel). 2020;12(12)doi: 10.3390/cancers12123788.
Saggese, P., Sellitto, A., Martinez, C. A., Giurato, G., Nassa, G., Rizzo, F., Tarallo, R., & Scafoglio, C. (2020). Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer. Cancers, 12(12), . https://doi.org/10.3390/cancers12123788
Saggese, Pasquale, et al. "Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer." Cancers vol. 12,12 (2020). doi: https://doi.org/10.3390/cancers12123788
Saggese P, Sellitto A, Martinez CA, Giurato G, Nassa G, Rizzo F, Tarallo R, Scafoglio C. Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer. Cancers (Basel). 2020 Dec 16;12(12). doi: 10.3390/cancers12123788. PMID: 33339101; PMCID: PMC7765496.
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Cancers (Basel). 2020 Dec 16;12(12). doi: 10.3390/cancers12123788.

Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer.

Cancers

Pasquale Saggese, Assunta Sellitto, Cesar A Martinez, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Roberta Tarallo, Claudio Scafoglio

Affiliations

  1. Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  2. Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Baronissi (SA), Italy.

PMID: 33339101 PMCID: PMC7765496 DOI: 10.3390/cancers12123788

Abstract

Metabolic reprogramming is a hallmark of cancer, with consistent rewiring of glucose, glutamine, and mitochondrial metabolism. While these metabolic alterations are adequate to meet the metabolic needs of cell growth and proliferation, the changes in critical metabolites have also consequences for the regulation of the cell differentiation state. Cancer evolution is characterized by progression towards a poorly differentiated, stem-like phenotype, and epigenetic modulation of the chromatin structure is an important prerequisite for the maintenance of an undifferentiated state by repression of lineage-specific genes. Epigenetic modifiers depend on intermediates of cellular metabolism both as substrates and as co-factors. Therefore, the metabolic reprogramming that occurs in cancer likely plays an important role in the process of the de-differentiation characteristic of the neoplastic process. Here, we review the epigenetic consequences of metabolic reprogramming in cancer, with particular focus on the role of mitochondrial intermediates and hypoxia in the regulation of cellular de-differentiation. We also discuss therapeutic implications.

Keywords: cancer epigenetics; cancer metabolism; cell differentiation in cancer; mitochondrial metabolism

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