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Ohtsuka K, Baba R, Yamasawa W, et al. The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome. Respiration. 2020;100(3):193-200doi: 10.1159/000512319.
Ohtsuka, K., Baba, R., Yamasawa, W., Shirahama, R., Hattori, Y., Senoura, H., Betsuyaku, T., & Fukunaga, K. (2021). The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome. Respiration; international review of thoracic diseases, 100(3), 193-200. https://doi.org/10.1159/000512319
Ohtsuka, Kengo, et al. "The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome." Respiration; international review of thoracic diseases vol. 100,3 (2021): 193-200. doi: https://doi.org/10.1159/000512319
Ohtsuka K, Baba R, Yamasawa W, Shirahama R, Hattori Y, Senoura H, Betsuyaku T, Fukunaga K. The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome. Respiration. 2021;100(3):193-200. doi: 10.1159/000512319. Epub 2020 Dec 28. PMID: 33370725.
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Respiration. 2021;100(3):193-200. doi: 10.1159/000512319. Epub 2020 Dec 28.

The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome.

Respiration; international review of thoracic diseases

Kengo Ohtsuka, Rie Baba, Wakako Yamasawa, Ryutaro Shirahama, Yoichiro Hattori, Hiroshi Senoura, Tomoko Betsuyaku, Koichi Fukunaga

Affiliations

  1. Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan, [email protected].
  2. Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  3. Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.
  4. RESM Shin Yokohama Sleep & Respiratory Medical Care Clinic, Kanagawa, Japan.
  5. Kichijyouji Sleep Medical Clinic, Tokyo, Japan.
  6. Shinjuku Sleep Medical Clinic, Tokyo, Japan.

PMID: 33370725 DOI: 10.1159/000512319

Abstract

BACKGROUND: Patients with obstructive sleep apnea syndrome (OSAS) experience excessive daytime sleepiness and insomnia and they are at risk of developing cardiovascular disease and stroke. Continuous positive airway pressure therapy could improve symptoms and decrease these risks; however, adherence is problematic. Although the oral appliance is another therapeutic option, patient satisfaction is limited and the effect of the nasal airway stent - a new device - remains unclear.

OBJECTIVES: The aim of this study was to evaluate the effect of NAS therapy in patients with mild-to-moderate OSAS in a prospective, single-arm, interventional pilot study.

METHOD: Patients with mild/moderate sleep apnea (n = 71; Apnea-Hypopnea Index [AHI], 5-20 events/h on polysomnography) were recruited. Sleep-associated events were measured using a portable device (WatchPAT200) pre- and immediately post-treatment and at 1 month follow-up. AHI (including supine and non-supine AHI), Oxygen Desaturation Index (ODI), Respiratory Disturbance Index (RDI), percutaneous oxygen saturation, heart rate, and snore volume were evaluated. Symptoms were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Hospital Anxiety and Depression Scale.

RESULTS: NAS use significantly improved AHI, supine AHI, RD, ODI, and snore volume compared to pre-intervention (r = 0.44, 0.48, 0.3, 0.42, and 0.34; p < 0.001, p < 0.001, p = 0.011, p < 0.001, and p = 0.048, respectively). Additionally, 25 and 10% of patients showed complete and partial response for AHI, respectively; these improvements remained significant 1 month later. Pittsburgh Sleep Quality Index scores improved from 6.0 to 5.3 (r = 0.46, p = 0.022).

CONCLUSIONS: NAS therapy reduced severity and snoring in patients with mild-to-moderate OSAS. Approximately 30% of patients did not tolerate NAS due to side effects.

© 2020 The Author(s) Published by S. Karger AG, Basel.

Keywords: Alternative therapy; Apnea-Hypopnea Index; Nasal airway stent; Obstructive sleep apnea syndrome; Snoring

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