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Vaccines (Basel). 2020 Dec 09;8(4). doi: 10.3390/vaccines8040745.

BCG Provides Short-Term Protection from Experimental Cerebral Malaria in Mice.

Vaccines

Julia Witschkowski, Jochen Behrends, Roland Frank, Lars Eggers, Linda von Borstel, David Hertz, Ann-Kristin Mueller, Bianca E Schneider

Affiliations

  1. Junior Research Group Coinfection, Priority Area Infections, Research Center Borstel-Leibniz Lung Center, 23845 Borstel, Germany.
  2. Core Facility Fluorescence Cytometry, Research Center Borstel-Leibniz Lung Center, 23845 Borstel, Germany.
  3. Centre for Infectious Diseases, Parasitology Unit, Heidelberg University Hospital, 69120 Heidelberg, Germany.
  4. German Center for Infection Research (DZIF), TTU Malaria, 69120 Heidelberg, Germany.

PMID: 33316929 PMCID: PMC7768457 DOI: 10.3390/vaccines8040745

Abstract

Clinical and experimental evidence suggests that the tuberculosis vaccine BCG offers protection against unrelated pathogens including the malaria parasite. Cerebral malaria (CM) is the most severe complication associated with

Keywords: BCG; Plasmodium berghei ANKA; experimental cerebral malaria; heterologous immunity; non-specific protection

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