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Calderon-Ospina CA, Nava-Mesa MO, Paez-Hurtado AM. Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review. Ther Clin Risk Manag. 2020;16:1275-1288doi: 10.2147/TCRM.S274122.
Calderon-Ospina, C. A., Nava-Mesa, M. O., & Paez-Hurtado, A. M. (2020). Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review. Therapeutics and clinical risk management, 161275-1288. https://doi.org/10.2147/TCRM.S274122
Calderon-Ospina, Carlos-Alberto, et al. "Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review." Therapeutics and clinical risk management vol. 16 (2020): 1275-1288. doi: https://doi.org/10.2147/TCRM.S274122
Calderon-Ospina CA, Nava-Mesa MO, Paez-Hurtado AM. Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review. Ther Clin Risk Manag. 2020 Dec 22;16:1275-1288. doi: 10.2147/TCRM.S274122. eCollection 2020. PMID: 33376337; PMCID: PMC7764703.
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Ther Clin Risk Manag. 2020 Dec 22;16:1275-1288. doi: 10.2147/TCRM.S274122. eCollection 2020.

Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review.

Therapeutics and clinical risk management

Carlos-Alberto Calderon-Ospina, Mauricio Orlando Nava-Mesa, Ana María Paez-Hurtado

Affiliations

  1. Center for Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  2. Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

PMID: 33376337 PMCID: PMC7764703 DOI: 10.2147/TCRM.S274122

Abstract

The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations (eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development. Because it warrants continued consideration, we also provide an update on neurotoxicity associated with vitamin B6. We consider that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration. The benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is therefore considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.

© 2020 Calderon-Ospina et al.

Keywords: cobalamin; hip fracture; lung cancer; neurotoxicity; neurotropic B vitamins; pyridoxine; safety; thiamine

Conflict of interest statement

The work was funded by P&G Health International. C. Calderon-Ospina holds consultative activities for P&G Health International and reports personal fees from them outside the submitted work. The autho

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