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De La Flor JC, Alonso M, Sandoval E, et al. Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature. Case Rep Nephrol. 2020;2020:6679857doi: 10.1155/2020/6679857.
De La Flor, J. C., Alonso, M., Sandoval, E., Marschall, A., & Rodeles, M. (2020). Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature. Case reports in nephrology, 20206679857. https://doi.org/10.1155/2020/6679857
De La Flor, José C, et al. "Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature." Case reports in nephrology vol. 2020 (2020): 6679857. doi: https://doi.org/10.1155/2020/6679857
De La Flor JC, Alonso M, Sandoval E, Marschall A, Rodeles M. Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature. Case Rep Nephrol. 2020 Dec 08;2020:6679857. doi: 10.1155/2020/6679857. eCollection 2020. PMID: 33376611; PMCID: PMC7738783.
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Case Rep Nephrol. 2020 Dec 08;2020:6679857. doi: 10.1155/2020/6679857. eCollection 2020.

Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature.

Case reports in nephrology

José C De La Flor, Marina Alonso, Edna Sandoval, Alexander Marschall, Miguel Rodeles

Affiliations

  1. Department of Nephrology, Hospital Central Defense Gomez Ulla, Madrid, Spain.
  2. Department of Anatomic Pathology, Hospital 12 de Octubre, Madrid, Spain.
  3. Department of Hematology, Hospital Central Defense Gomez Ulla, Madrid, Spain.
  4. Department of Cardiology, Hospital Central Defense Gomez Ulla, Madrid, Spain.

PMID: 33376611 PMCID: PMC7738783 DOI: 10.1155/2020/6679857

Abstract

We present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her evolution a relapse. Although the bone marrow biopsy in this case showed plasma cells as pathologic clone and there was also a reduction after chemotherapeutic treatment, rituximab was proposed as a second line. We suspected that the relapse was possibly due to another precursor as B-cell or lymphoplasmacytic cell clone. We review the literature and suggest that the treatment for MGRS should be patient-tailored, preferably by consulting a multidisciplinary team. Future research is needed to better understand the disease course and establish the efficacy and safety of the therapeutic approach for the relapse of MGRS.

Copyright © 2020 José C. De La Flor et al.

Conflict of interest statement

The authors declare no conflicts of interest for this study.

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