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Paradee N, Koonyosying P, Kusirisin W, et al. Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals. Biosci Rep. 2021;41(1)doi: 10.1042/BSR20203166.
Paradee, N., Koonyosying, P., Kusirisin, W., Janthip, R., Kanjanapothi, D., Pattanapanyasat, K., & Srichairatanakool, S. (2021). Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals. Bioscience reports, 41(1), . https://doi.org/10.1042/BSR20203166
Paradee, Narisara, et al. "Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals." Bioscience reports vol. 41,1 (2021). doi: https://doi.org/10.1042/BSR20203166
Paradee N, Koonyosying P, Kusirisin W, Janthip R, Kanjanapothi D, Pattanapanyasat K, Srichairatanakool S. Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals. Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20203166. PMID: 33399183; PMCID: PMC7823181.
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Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20203166.

Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals.

Bioscience reports

Narisara Paradee, Pimpisid Koonyosying, Winthana Kusirisin, Rattanaporn Janthip, Duangta Kanjanapothi, Kovit Pattanapanyasat, Somdet Srichairatanakool

Affiliations

  1. Oxidative Stress Cluster, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
  2. Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
  3. Faculty of Pharmacy, Payap University, Chiang Mai, Thailand.
  4. Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

PMID: 33399183 PMCID: PMC7823181 DOI: 10.1042/BSR20203166

Abstract

Perilla frutescens fruit oil (PFO) is rich in α-linolenic acid (ALA) and exhibits biological activities. We aimed to investigate analgesic, anti-inflammatory and anti-ulcer activities of PFO and PFO-supplemented soybean milk (PFO-SM) in animal models. Analgesic activity was assessed in acetic acid-induced writhing in mice, while anti-inflammatory activity was performed in ethyl phenylpropiolate (EPP)-induced ear edema and carrageenan-induced hind paw edema in rats. Anti-ulcer effects were conducted in water immersion stress, HCl/ethanol and indomethacin-induced gastric ulcer in rats. Distinctly, PFO, containing 6.96 mg ALA and 2.61 mg LA equivalence/g, did not induce acute toxicity (LD50 > 10 mL/kg) in mice. PFO (2.5 and 5 mL/kg) and PFO-SM (0.05 mL PFO equivalence/kg) inhibited incidences of writhing (16.8, 18.0 and 32.3%, respectively) in acetic acid-induced mice. In addition, topical applications of PFO (0.1 and 1 mL/ear) significantly inhibited EPP-induced ear edema (59.3 and 65.7%, respectively) in rats, while PFO-SM slightly inhibited ear edema (25.9%). However, PFO and PFO-SM did not inhibit carrageenan-induced hind paw edema in rats. Indeed, PFO (2.5 and 5 mL/kg) significantly inhibited gastric ulcers in rats that induced by water immersion stress (92.4 and 96.6%, respectively), HCl/ethanol (74.8 and 73.3%, respectively) and indomethacin (68.8 and 88.9%, respectively), while PFO-SM did not. PFO displayed potent analgesic, anti-inflammatory and anti-ulcer properties, while PFO-SM exerted only analgesic properties. Thus, Thai PFO and its functional drink offer potential benefits in treatment of analgesic, inflammatory diseases and gastric ulcer.

© 2021 The Author(s).

Keywords: Perilla frutescence; analgesic; anti-inflammatory; anti-ulcer; fruit oil

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