Display options
Cite
Tenforde MW, Talbot HK, Trabue CH, et al. Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019-2020. J Infect Dis. 2021;224(5):813-820doi: 10.1093/infdis/jiaa800.
Tenforde, M. W., Talbot, H. K., Trabue, C. H., Gaglani, M., McNeal, T. M., Monto, A. S., Martin, E. T., Zimmerman, R. K., Silveira, F. P., Middleton, D. B., Olson, S. M., Garten Kondor, R. J., Barnes, J. R., Ferdinands, J. M., Patel, M. M. (2021). Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019-2020. The Journal of infectious diseases, 224(5), 813-820. https://doi.org/10.1093/infdis/jiaa800
Tenforde, Mark W, et al. "Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019-2020." The Journal of infectious diseases vol. 224,5 (2021): 813-820. doi: https://doi.org/10.1093/infdis/jiaa800
Tenforde MW, Talbot HK, Trabue CH, Gaglani M, McNeal TM, Monto AS, Martin ET, Zimmerman RK, Silveira FP, Middleton DB, Olson SM, Garten Kondor RJ, Barnes JR, Ferdinands JM, Patel MM. Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019-2020. J Infect Dis. 2021 Sep 01;224(5):813-820. doi: 10.1093/infdis/jiaa800. PMID: 33378531; PMCID: PMC8408767.
Copy Download .nbib Format: NLM
Share it on

J Infect Dis. 2021 Sep 01;224(5):813-820. doi: 10.1093/infdis/jiaa800.

Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019-2020.

The Journal of infectious diseases

Mark W Tenforde, H Keipp Talbot, Christopher H Trabue, Manjusha Gaglani, Tresa M McNeal, Arnold S Monto, Emily T Martin, Richard K Zimmerman, Fernanda P Silveira, Donald B Middleton, Samantha M Olson, Rebecca J Garten Kondor, John R Barnes, Jill M Ferdinands, Manish M Patel,

Affiliations

  1. Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  2. Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  3. University of Tennessee Health Science Center, Saint Thomas Health, Nashville, Tennessee, USA.
  4. Baylor Scott and White Health, Texas A&M University College of Medicine, Temple, Texas, USA.
  5. University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  6. University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

PMID: 33378531 PMCID: PMC8408767 DOI: 10.1093/infdis/jiaa800

Abstract

BACKGROUND: Influenza causes significant morbidity and mortality and stresses hospital resources during periods of increased circulation. We evaluated the effectiveness of the 2019-2020 influenza vaccine against influenza-associated hospitalization in the United States.

METHODS: We included adults hospitalized with acute respiratory illness at 14 hospitals and tested for influenza viruses by reserve-transcription polymerase chain reaction. Vaccine effectiveness (VE) was estimated by comparing the odds of current-season influenza vaccination in test-positive influenza cases vs test-negative controls, adjusting for confounders. VE was stratified by age and major circulating influenza types along with A(H1N1)pdm09 genetic subgroups.

RESULTS: A total of 3116 participants were included, including 18% (n = 553) influenza-positive cases. Median age was 63 years. Sixty-seven percent (n = 2079) received vaccination. Overall adjusted VE against influenza viruses was 41% (95% confidence interval [CI], 27%-52%). VE against A(H1N1)pdm09 viruses was 40% (95% CI, 24%-53%) and 33% against B viruses (95% CI, 0-56%). Of the 2 major A(H1N1)pdm09 subgroups (representing 90% of sequenced H1N1 viruses), VE against one group (5A + 187A,189E) was 59% (95% CI, 34%-75%) whereas no VE was observed against the other group (5A + 156K) (-1% [95% CI, -61% to 37%]).

CONCLUSIONS: In a primarily older population, influenza vaccination was associated with a 41% reduction in risk of hospitalized influenza illness.

Published by Oxford University Press for the Infectious Diseases Society of America 2020.

Keywords: elderly; hospitalization; immunocompromised; influenza; vaccine effectiveness

Publication Types

Grant support