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Bitossi C, Frasca F, Viscido A, et al. SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients. Microorganisms. 2021;9(1)doi: 10.3390/microorganisms9010093.
Bitossi, C., Frasca, F., Viscido, A., Oliveto, G., Scordio, M., Belloni, L., Cimino, G., Pietropaolo, V., Gentile, M., d'Ettorre, G., Midulla, F., Trancassini, M., Antonelli, G., Pierangeli, A., & Scagnolari, C. (2021). SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients. Microorganisms, 9(1), . https://doi.org/10.3390/microorganisms9010093
Bitossi, Camilla, et al. "SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients." Microorganisms vol. 9,1 (2021). doi: https://doi.org/10.3390/microorganisms9010093
Bitossi C, Frasca F, Viscido A, Oliveto G, Scordio M, Belloni L, Cimino G, Pietropaolo V, Gentile M, d'Ettorre G, Midulla F, Trancassini M, Antonelli G, Pierangeli A, Scagnolari C. SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients. Microorganisms. 2021 Jan 03;9(1). doi: 10.3390/microorganisms9010093. PMID: 33401565; PMCID: PMC7824643.
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Microorganisms. 2021 Jan 03;9(1). doi: 10.3390/microorganisms9010093.

SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.

Microorganisms

Camilla Bitossi, Federica Frasca, Agnese Viscido, Giuseppe Oliveto, Mirko Scordio, Laura Belloni, Giuseppe Cimino, Valeria Pietropaolo, Massimo Gentile, Gabriella d'Ettorre, Fabio Midulla, Maria Trancassini, Guido Antonelli, Alessandra Pierangeli, Carolina Scagnolari

Affiliations

  1. Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, Sapienza University, 00161 Rome, Italy.
  2. Department of Internal Medicine, Sapienza University, 00161 Rome, Italy.
  3. Lazio Reference Center for Cystic Fibrosis, Policlinico Umberto I University Hospital, Sapienza University, 00161 Rome, Italy.
  4. Department of Public Health and Infectious Diseases, Sapienza University, 00161 Rome, Italy.
  5. Microbiology and Virology Unit, Policlinico Umberto I University Hospital, Sapienza University, 00161 Rome, Italy.
  6. Department of Maternal Science, Sapienza University of Rome, 00161 Rome, Italy.

PMID: 33401565 PMCID: PMC7824643 DOI: 10.3390/microorganisms9010093

Abstract

The expression rate of SARS-CoV-2 entry genes, angiotensin-converting enzyme 2 (ACE2), the main viral receptor and the proteases, furin and transmembrane serine protease 2 (TMPRSS2) in cystic fibrosis (CF) individuals is poorly known. Hence, we examined their levels in upper respiratory samples of CF patients (

Keywords: ACE2; ISG15; SARS-CoV-2; TMPRSS2; cystic fibrosis; dACE2; furin; interferon

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