Display options
Cite
Nalamachu SR, Robinson RL, Viktrup L, et al. Multimodal Treatment Patterns for Osteoarthritis and Their Relationship to Patient-Reported Pain Severity: A Cross-Sectional Survey in the United States. J Pain Res. 2020;13:3415-3425doi: 10.2147/JPR.S285124.
Nalamachu, S. R., Robinson, R. L., Viktrup, L., Cappelleri, J. C., Bushmakin, A. G., Tive, L., Mellor, J., Hatchell, N., & Jackson, J. (2020). Multimodal Treatment Patterns for Osteoarthritis and Their Relationship to Patient-Reported Pain Severity: A Cross-Sectional Survey in the United States. Journal of pain research, 133415-3425. https://doi.org/10.2147/JPR.S285124
Nalamachu, Srinivas R, et al. "Multimodal Treatment Patterns for Osteoarthritis and Their Relationship to Patient-Reported Pain Severity: A Cross-Sectional Survey in the United States." Journal of pain research vol. 13 (2020): 3415-3425. doi: https://doi.org/10.2147/JPR.S285124
Nalamachu SR, Robinson RL, Viktrup L, Cappelleri JC, Bushmakin AG, Tive L, Mellor J, Hatchell N, Jackson J. Multimodal Treatment Patterns for Osteoarthritis and Their Relationship to Patient-Reported Pain Severity: A Cross-Sectional Survey in the United States. J Pain Res. 2020 Dec 23;13:3415-3425. doi: 10.2147/JPR.S285124. eCollection 2020. PMID: 33380823; PMCID: PMC7767791.
Copy Download .nbib Format: NLM
Share it on

J Pain Res. 2020 Dec 23;13:3415-3425. doi: 10.2147/JPR.S285124. eCollection 2020.

Multimodal Treatment Patterns for Osteoarthritis and Their Relationship to Patient-Reported Pain Severity: A Cross-Sectional Survey in the United States.

Journal of pain research

Srinivas R Nalamachu, Rebecca L Robinson, Lars Viktrup, Joseph C Cappelleri, Andrew G Bushmakin, Leslie Tive, Jennifer Mellor, Niall Hatchell, James Jackson

Affiliations

  1. Mid America PolyClinic, Overland Park, KS, USA.
  2. Patient Outcomes and Real-World Evidence, Eli Lilly and Company, Indianapolis, IN, USA.
  3. Lilly Bio-Medicines Core Team, Eli Lilly and Company, Indianapolis, IN, USA.
  4. Statistics, Pfizer Inc, Groton, CT, USA.
  5. Medical Affairs, Pfizer Inc, New York, NY, USA.
  6. Real World Research, Adelphi Real World, Bollington, Cheshire, UK.

PMID: 33380823 PMCID: PMC7767791 DOI: 10.2147/JPR.S285124

Abstract

PURPOSE: The purpose of this study was to assess how patient-reported pain is related to osteoarthritis (OA) treatment patterns in routine clinical practice.

PATIENTS AND METHODS: Data were collected between February and May 2017 from 153 United States (US) primary care physicians, rheumatologists, and orthopedic surgeons. Each invited up to nine consecutive patients to rate their OA pain in the last week. Physicians provided demographic, clinical, and treatment information for patients, including nonpharmacologic therapies ever recommended, currently recommended over-the-counter (OTC) medications, and currently and ever prescribed medications for the management of OA. Findings for patients with mild (0─3), moderate (4─6), and severe current pain (7─10) were compared using appropriate statistics.

RESULTS: Among the 841 patients (61% female; mean 65 years; 57% knee OA), 45% reported mild, 36% moderate, and 19% severe current OA pain. Current treatment modalities differed by pain severity (

CONCLUSION: Real-life treatment patterns for OA in the US are significantly associated with current patient-reported pain. Combining nonpharmacologic and pharmacologic treatments is common but higher pain ratings are associated with multiple failed prescription treatments. Current use of acetaminophen and opioids, but not NSAIDs, increases alongside pain severity.

© 2020 Nalamachu et al.

Keywords: nonprescription drugs; pain management; physicians; practice patterns; prescription drugs; therapeutics

Conflict of interest statement

SRN is a consultant/speaker and received honorarium from Pfizer and Eli Lilly and Company. RLR and LV are employees and stockholders of Eli Lilly and Company. JCC, AGB, and LT are employees of Pfizer

References

  1. Osteoarthritis Cartilage. 2008 Feb;16(2):137-62 - PubMed
  2. Arthritis Rheumatol. 2020 Feb;72(2):220-233 - PubMed
  3. Cochrane Database Syst Rev. 2014 Sep 17;(9):CD003115 - PubMed
  4. MMWR Morb Mortal Wkly Rep. 2018 Jan 04;67(5152):1419-1427 - PubMed
  5. Arthritis Res Ther. 2013;15(5):R106 - PubMed
  6. Arthritis Care Res (Hoboken). 2014 Oct;66(10):1489-95 - PubMed
  7. Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):75-78 - PubMed
  8. Arthritis Rheum. 2008 Jan;58(1):26-35 - PubMed
  9. Ann Intern Med. 2015 Feb 17;162(4):276-86 - PubMed
  10. Arthritis Care Res (Hoboken). 2016 Apr;68(4):481-92 - PubMed
  11. Osteoarthritis Cartilage. 2013 Sep;21(9):1145-53 - PubMed
  12. Arthritis Res Ther. 2010;12(4):R162 - PubMed
  13. Osteoarthritis Cartilage. 2014 Mar;22(3):363-88 - PubMed
  14. Osteoarthritis Cartilage. 2019 Nov;27(11):1578-1589 - PubMed
  15. Int J Technol Assess Health Care. 2003 Winter;19(1):57-70 - PubMed
  16. JAMA. 2016 Apr 19;315(15):1624-45 - PubMed
  17. Biometrika. 1951 Jun;38(1-2):141-9 - PubMed
  18. Curr Med Res Opin. 2013 May;29(5):539-48 - PubMed
  19. Curr Med Res Opin. 2008 Nov;24(11):3063-72 - PubMed
  20. JAMA. 2018 Mar 6;319(9):872-882 - PubMed
  21. MMWR Morb Mortal Wkly Rep. 2017 Mar 10;66(9):246-253 - PubMed
  22. Semin Arthritis Rheum. 2014 Jun;43(6):701-12 - PubMed
  23. J Chronic Dis. 1987;40(5):373-83 - PubMed
  24. Arthritis Rheumatol. 2014 Aug;66(8):2134-43 - PubMed
  25. BMJ Open. 2015 Dec 11;5(12):e007568 - PubMed
  26. MMWR Morb Mortal Wkly Rep. 2016 Dec 30;65(50-51):1445-1452 - PubMed
  27. Pain Pract. 2012 Nov;12(8):633-40 - PubMed
  28. Ann Rheum Dis. 2011 May;70(5):740-6 - PubMed
  29. Arthritis Care Res (Hoboken). 2012 Apr;64(4):465-74 - PubMed
  30. Rheum Dis Clin North Am. 2013 Feb;39(1):123-43 - PubMed
  31. J Arthroplasty. 2017 Dec;32(12):3578-3582.e1 - PubMed
  32. J Rheumatol. 2007 Mar;34(3):543-55 - PubMed

Publication Types