Display options
Cite
Hunt PJ, Kabotyanski KE, Calin GA, et al. Interrupting Neuron-Tumor Interactions to Overcome Treatment Resistance. Cancers (Basel). 2020;12(12)doi: 10.3390/cancers12123741.
Hunt, P. J., Kabotyanski, K. E., Calin, G. A., Xie, T., Myers, J. N., & Amit, M. (2020). Interrupting Neuron-Tumor Interactions to Overcome Treatment Resistance. Cancers, 12(12), . https://doi.org/10.3390/cancers12123741
Hunt, Patrick J, et al. "Interrupting Neuron-Tumor Interactions to Overcome Treatment Resistance." Cancers vol. 12,12 (2020). doi: https://doi.org/10.3390/cancers12123741
Hunt PJ, Kabotyanski KE, Calin GA, Xie T, Myers JN, Amit M. Interrupting Neuron-Tumor Interactions to Overcome Treatment Resistance. Cancers (Basel). 2020 Dec 12;12(12). doi: 10.3390/cancers12123741. PMID: 33322770; PMCID: PMC7762969.
Copy Download .nbib Format: NLM
Share it on

Cancers (Basel). 2020 Dec 12;12(12). doi: 10.3390/cancers12123741.

Interrupting Neuron-Tumor Interactions to Overcome Treatment Resistance.

Cancers

Patrick J Hunt, Katherine E Kabotyanski, George A Calin, Tongxin Xie, Jeffrey N Myers, Moran Amit

Affiliations

  1. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA.
  2. Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  3. Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
  4. Translational Molecular Pathology, Division of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  5. Department of Head and Neck Surgery, Division of Surgery, MD Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 33322770 PMCID: PMC7762969 DOI: 10.3390/cancers12123741

Abstract

Neurons in the tumor microenvironment release neurotransmitters, neuroligins, chemokines, soluble growth factors, and membrane-bound growth factors that solid tumors leverage to drive their own survival and spread. Tumors express nerve-specific growth factors and microRNAs that support local neurons and guide neuronal growth into tumors. The development of feed-forward relationships between tumors and neurons allows tumors to use the perineural space as a sanctuary from therapy. Tumor denervation slows tumor growth in animal models, demonstrating the innervation dependence of growing tumors. Further in vitro and in vivo experiments have identified many of the secreted signaling molecules (e.g., acetylcholine, nerve growth factor) that are passed between neurons and cancer cells, as well as the major signaling pathways (e.g., MAPK/EGFR) involved in these trophic interactions. The molecules involved in these signaling pathways serve as potential biomarkers of disease. Additionally, new treatment strategies focus on using small molecules, receptor agonists, nerve-specific toxins, and surgical interventions to target tumors, neurons, and immune cells of the tumor microenvironment, thereby severing the interactions between tumors and surrounding neurons. This article discusses the mechanisms underlying the trophic relationships formed between neurons and tumors and explores the emerging therapies stemming from this work.

Keywords: cancer progression; microRNA; neurotrophic growth; tumor microenvironment

References

  1. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7925-30 - PubMed
  2. Acta Neuropathol. 2010 Jan;119(1):7-35 - PubMed
  3. Brain Behav Immun. 2014 Aug;40:40-7 - PubMed
  4. Science. 2013 Jul 12;341(6142):1236361 - PubMed
  5. J Neuroimmune Pharmacol. 2013 Mar;8(1):7-14 - PubMed
  6. PLoS One. 2013 Jul 30;8(7):e70616 - PubMed
  7. Nat Commun. 2018 Oct 16;9(1):4284 - PubMed
  8. PLoS One. 2011 Apr 29;6(4):e19246 - PubMed
  9. Prostate. 2011 Feb 15;71(3):326-31 - PubMed
  10. Nat Rev Cancer. 2020 Mar;20(3):143-157 - PubMed
  11. Clin Cancer Res. 2006 Jan 15;12(2):369-75 - PubMed
  12. Cancer Cell. 2018 Apr 9;33(4):736-751.e5 - PubMed
  13. Trends Neurosci. 2012 Nov;35(11):691-9 - PubMed
  14. Clin Cancer Res. 2011 Apr 1;17(7):1741-52 - PubMed
  15. Histochem Cell Biol. 2013 Mar;139(3):431-45 - PubMed
  16. Cancer Res. 1999 May 15;59(10):2395-401 - PubMed
  17. Cancer Res. 2018 Jun 15;78(12):3233-3242 - PubMed
  18. PLoS One. 2012;7(3):e30679 - PubMed
  19. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11464-9 - PubMed
  20. J Exp Clin Cancer Res. 2008 Nov 04;27:62 - PubMed
  21. Nat Rev Clin Oncol. 2014 Mar;11(3):145-56 - PubMed
  22. J Surg Oncol. 2012 Aug 1;106(2):188-92 - PubMed
  23. Cancer. 2009 Aug 1;115(15):3379-91 - PubMed
  24. Cell. 2019 Apr 4;177(2):463-477.e15 - PubMed
  25. Dev Cell. 2015 Feb 23;32(4):390-407 - PubMed
  26. Cancer. 1967 Oct;20(10):1772-9 - PubMed
  27. Nature. 2012 Jul 26;487(7408):500-4 - PubMed
  28. Cancer Res. 2002 Jun 1;62(11):3298-307 - PubMed
  29. Prostate. 2018 Feb;78(2):128-139 - PubMed
  30. Prostate. 2001 Nov 1;49(3):213-23 - PubMed
  31. Trends Cancer. 2017 Feb;3(2):89-112 - PubMed
  32. Mol Cell Biochem. 2015 Feb;400(1-2):287-95 - PubMed
  33. Mass Spectrom Rev. 2015 Jul-Aug;34(4):474-90 - PubMed
  34. Neuron. 2011 Aug 11;71(3):406-24 - PubMed
  35. Front Immunol. 2018 Feb 06;9:164 - PubMed
  36. Pain. 2011 Nov;152(11):2564-74 - PubMed
  37. Nature. 2019 Sep;573(7775):526-531 - PubMed
  38. Clin Cancer Res. 1999 Aug;5(8):2205-12 - PubMed
  39. Nat Med. 2013 Nov;19(11):1423-37 - PubMed
  40. Clin Cancer Res. 2003 Nov 1;9(14):5127-36 - PubMed
  41. Cancer Discov. 2018 Nov;8(11):1458-1473 - PubMed
  42. Chin J Cancer. 2011 Jun;30(6):407-14 - PubMed
  43. Cell. 2020 Sep 17;182(6):1531-1544.e15 - PubMed
  44. Ann Surg. 1993 May;217(5):447-55; discussion 456-7 - PubMed
  45. Hum Pathol. 2014 Jul;45(7):1358-64 - PubMed
  46. Oncotarget. 2016 Aug 23;7(34):55506-55517 - PubMed
  47. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7 - PubMed
  48. Mol Oncol. 2015 Oct;9(8):1626-35 - PubMed
  49. Oncol Lett. 2019 Nov;18(5):5523-5533 - PubMed
  50. Sci Rep. 2017 Jan 19;7:40802 - PubMed
  51. Acta Pharmacol Sin. 2004 Oct;25(10):1354-60 - PubMed
  52. PLoS One. 2016 Oct 28;11(10):e0165586 - PubMed
  53. Sci Rep. 2016 Jul 26;6:30404 - PubMed
  54. Nat Rev Urol. 2020 Feb;17(2):119-130 - PubMed
  55. J Biol Chem. 2007 Oct 12;282(41):29919-26 - PubMed
  56. Clin Cancer Res. 2001 Aug;7(8):2237-45 - PubMed
  57. Am J Pathol. 2014 Dec;184(12):3156-62 - PubMed
  58. Open Biol. 2017 Dec;7(12): - PubMed
  59. Tumour Biol. 2016 Feb;37(2):2105-17 - PubMed
  60. Nature. 2015 Nov 19;527(7578):329-35 - PubMed
  61. Glia. 2019 Sep;67(9):1637-1653 - PubMed
  62. Neurochem Int. 2012 Dec;61(8):1266-75 - PubMed
  63. Science. 1999 Oct 15;286(5439):548-52 - PubMed
  64. J Plast Reconstr Aesthet Surg. 2018 Jun;71(6):833-839 - PubMed
  65. Eur Urol. 2014 Mar;65(3):635-41 - PubMed
  66. Curr Neuropharmacol. 2016;14(8):967-972 - PubMed
  67. Med Oncol. 2014 Jan;31(1):805 - PubMed
  68. Cancer Res. 2001 Apr 1;61(7):2866-9 - PubMed
  69. Clin Cancer Res. 2012 Mar 1;18(5):1201-6 - PubMed
  70. Cell. 2005 Feb 11;120(3):421-33 - PubMed
  71. Mol Oncol. 2013 Jun;7(3):334-45 - PubMed
  72. Annu Rev Pharmacol Toxicol. 2020 Jul 6;: - PubMed
  73. Cancer Res. 2016 Dec 1;76(23):6851-6863 - PubMed
  74. Nat Rev Clin Oncol. 2018 Apr;15(4):234-248 - PubMed
  75. Science. 2017 Jan 6;355(6320):84-88 - PubMed
  76. Annu Rev Cell Dev Biol. 2019 Oct 6;35:615-635 - PubMed
  77. Cell Death Differ. 2005 Aug;12(8):1044-56 - PubMed
  78. Trends Neurosci. 1989 Jul;12(7):265-70 - PubMed
  79. Nat Rev Clin Oncol. 2018 Feb;15(2):81-94 - PubMed
  80. PLoS One. 2012;7(4):e34210 - PubMed
  81. Int J Biol Sci. 2017 Feb 12;13(3):286-294 - PubMed
  82. Diabetes. 2014 Jul;63(7):2232-43 - PubMed
  83. Ann Oncol. 2013 May;24(5):1312-9 - PubMed
  84. Biochim Biophys Acta. 2011 Dec;1816(2):105-18 - PubMed
  85. Nature. 2020 Feb;578(7795):449-454 - PubMed
  86. Cancer. 2011 Nov 1;117(21):4834-45 - PubMed
  87. Cell Commun Signal. 2010 Sep 07;8:21 - PubMed
  88. FASEB J. 2020 Jul;34(7):9087-9101 - PubMed
  89. J Biol Chem. 2010 Nov 12;285(46):35462-70 - PubMed
  90. Biochim Biophys Acta. 2016 Aug;1866(1):37-50 - PubMed
  91. Brain Res. 1987 Apr 21;409(2):215-20 - PubMed
  92. Cancers (Basel). 2011 Feb 01;3(1):510-30 - PubMed
  93. Annu Rev Cell Biol. 1991;7:117-59 - PubMed
  94. Cell. 2013 Mar 28;153(1):86-100 - PubMed
  95. Carcinogenesis. 2000 Oct;21(10):1789-93 - PubMed
  96. Nat Med. 1998 Nov;4(11):1313-7 - PubMed
  97. Curr Opin Neurobiol. 1996 Feb;6(1):64-70 - PubMed
  98. Nature. 2015 Apr 16;520(7547):368-72 - PubMed
  99. Mol Cancer Ther. 2013 Mar;12(3):264-73 - PubMed
  100. Expert Rev Mol Diagn. 2015;15(9):1159-69 - PubMed
  101. Carcinogenesis. 2009 Jan;30(1):35-42 - PubMed
  102. Cancer Cell. 2020 Jul 13;38(1):11-14 - PubMed
  103. Cancer Gene Ther. 2017 Feb;24(2):48-56 - PubMed
  104. Nat Cell Biol. 2019 Nov;21(11):1403-1412 - PubMed
  105. Mol Cancer Res. 2015 Feb;13(2):380-90 - PubMed
  106. Methods Mol Biol. 2017;1633:257-265 - PubMed
  107. Nat Med. 2012 Jun;18(6):883-91 - PubMed
  108. Int J Mol Sci. 2018 Jan 27;19(2): - PubMed
  109. EXCLI J. 2014 Aug 18;13:843-55 - PubMed
  110. J Ovarian Res. 2020 Apr 26;13(1):47 - PubMed
  111. Cancer Cell. 2017 Jan 9;31(1):21-34 - PubMed
  112. Cell. 2020 Aug 20;182(4):1044-1061.e18 - PubMed
  113. J Invest Dermatol. 1990 Sep;95(3):325-32 - PubMed
  114. Am J Surg Pathol. 1980 Apr;4(2):143-8 - PubMed
  115. J Clin Med. 2019 Apr 26;8(5): - PubMed
  116. Nat Rev Cancer. 2016 Jun;16(6):399-408 - PubMed
  117. J Clin Oncol. 2011 Jul 1;29(19):2645-52 - PubMed
  118. Cells. 2019 Nov 25;8(12): - PubMed
  119. Breast Cancer Res Treat. 2003 Jul;80(1):63-70 - PubMed
  120. Nat Med. 2003 Apr;9(4):439-47 - PubMed
  121. Nat Neurosci. 2019 Aug;22(8):1289-1305 - PubMed
  122. Cancer Cell. 2018 Jan 8;33(1):75-90.e7 - PubMed
  123. Nat Rev Cancer. 2015 Sep;15(9):563-72 - PubMed
  124. Carcinogenesis. 2011 Sep;32(9):1396-402 - PubMed
  125. Cancer Res. 2012 Nov 15;72(22):5733-43 - PubMed
  126. Int J Oncol. 2007 Jan;30(1):193-200 - PubMed
  127. Nature. 2005 Jul 14;436(7048):193-200 - PubMed
  128. Bioessays. 2002 Sep;24(9):821-7 - PubMed
  129. J Biol Chem. 2010 Jul 9;285(28):21496-507 - PubMed
  130. Cell Stem Cell. 2015 Apr 2;16(4):400-12 - PubMed
  131. J Neurol Surg B Skull Base. 2016 Apr;77(2):96-106 - PubMed
  132. Sci Transl Med. 2014 Aug 20;6(250):250ra115 - PubMed
  133. Cancer. 2015 Oct 1;121(19):3444-51 - PubMed
  134. Cancer Res. 2010 Sep 15;70(18):7042-52 - PubMed
  135. Nat Cell Biol. 2015 Jun;17(6):816-26 - PubMed

Publication Types

Grant support