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Int J Tryptophan Res. 2020 Dec 15;13:1178646920978245. doi: 10.1177/1178646920978245. eCollection 2020.

[No title available]

International journal of tryptophan research : IJTR

Panyada Panyatip, Nadtanet Nunthaboot, Ploenthip Puthongking

Affiliations

  1. Graduate School, Khon Kaen University, Khon Kaen, Thailand.
  2. Melatonin Research Group, Khon Kaen University, Khon Kaen, Thailand.
  3. Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Maha Sarakham, Thailand.
  4. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.

PMID: 33402831 PMCID: PMC7745548 DOI: 10.1177/1178646920978245

Abstract

Melatonin (MLT) is a well-known pineal hormone possessed with remarkable biological activities. However, its low oral bioavailability and high first-pass metabolism rate are important pharmacokinetics problems. Therefore, 5 MLT derivatives (

© The Author(s) 2020.

Keywords: ADME; Melatonin; N-amide derivative; metabolism; molecular docking

Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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