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Marin PA, Obonaga R, Pavani RS, et al. ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in . Front Cell Dev Biol. 2020;8:602956doi: 10.3389/fcell.2020.602956.
Marin, P. A., Obonaga, R., Pavani, R. S., da Silva, M. S., de Araujo, C. B., Lima, A. A., Avila, C. C., Cestari, I., Machado, C. R., & Elias, M. C. (2020). ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in . Frontiers in cell and developmental biology, 8602956. https://doi.org/10.3389/fcell.2020.602956
Marin, Paula Andrea, et al. "ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in ." Frontiers in cell and developmental biology vol. 8 (2020): 602956. doi: https://doi.org/10.3389/fcell.2020.602956
Marin PA, Obonaga R, Pavani RS, da Silva MS, de Araujo CB, Lima AA, Avila CC, Cestari I, Machado CR, Elias MC. ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in . Front Cell Dev Biol. 2020 Dec 22;8:602956. doi: 10.3389/fcell.2020.602956. eCollection 2020. PMID: 33415107; PMCID: PMC7783291.
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Front Cell Dev Biol. 2020 Dec 22;8:602956. doi: 10.3389/fcell.2020.602956. eCollection 2020.

ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in .

Frontiers in cell and developmental biology

Paula Andrea Marin, Ricardo Obonaga, Raphael Souza Pavani, Marcelo Santos da Silva, Christiane Bezerra de Araujo, André Arruda Lima, Carla Cristi Avila, Igor Cestari, Carlos Renato Machado, Maria Carolina Elias

Affiliations

  1. Laboratory of Cell Cycle (LCC), Center of Toxins, Immune Response and Cell Signaling (CETICs), Butantan Institute, São Paulo, Brazil.
  2. Institute of Parasitology, McGill University, Montreal, QC, Canada.
  3. Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
  4. Biochemical and Immunology Department, Institute of Biomedical Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.

PMID: 33415107 PMCID: PMC7783291 DOI: 10.3389/fcell.2020.602956

Abstract

DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a checkpoint response to delay cell cycle progression, recruit the proper repair machinery, and resume the cell cycle once the DNA damage is repaired. Cell cycle checkpoints are primarily regulated by the apical kinases ATR and ATM, which are conserved throughout the eukaryotic kingdom.

Copyright © 2020 Marin, Obonaga, Pavani, da Silva, de Araujo, Lima, Avila, Cestari, Machado and Elias.

Keywords: ATR; DNA damage response; DNA double-strand breaks; RAD51; Trypanosoma brucei; checkpoint; γH2A

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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