Display options
Share it on

Pharmaceutics. 2020 Dec 18;12(12). doi: 10.3390/pharmaceutics12121235.

The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery.

Pharmaceutics

Simon Drescher, Peter van Hoogevest

Affiliations

  1. Phospholipid Research Center, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.

PMID: 33353254 PMCID: PMC7766331 DOI: 10.3390/pharmaceutics12121235

Abstract

This review summarizes the research on phospholipids and their use for drug delivery related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that have been approved by the PRC since 2017 and are currently still ongoing or have recently been completed. The different projects cover all facets of phospholipid research, from basic to applied research, including the use of phospholipids in different administration forms such as liposomes, mixed micelles, emulsions, and extrudates, up to industrial application-oriented research. These projects also include all routes of administration, namely parenteral, oral, and topical. With this review we would like to highlight possible future research directions, including a short introduction into the world of phospholipids.

Keywords: drug delivery; lecithin; oral; parenteral; phospholipids; topical

References

  1. Mol Pharm. 2019 Jan 7;16(1):141-150 - PubMed
  2. J Anesth. 2018 Aug;32(4):632-636 - PubMed
  3. PLoS One. 2014 Jan 22;9(1):e86147 - PubMed
  4. Am J Respir Crit Care Med. 1997 Apr;155(4):1309-15 - PubMed
  5. Int J Pharm. 2019 Jul 20;566:383-390 - PubMed
  6. J Pharm Sci. 1999 Sep;88(9):896-904 - PubMed
  7. Org Biomol Chem. 2020 May 13;18(18):3585-3598 - PubMed
  8. Prog Lipid Res. 1994;33(3):239-328 - PubMed
  9. Int J Pharm. 2019 Apr 5;560:191-204 - PubMed
  10. Eur J Pharm Biopharm. 2018 Nov;132:211-221 - PubMed
  11. Int J Pharm. 2020 Oct 15;588:119693 - PubMed
  12. Nanomaterials (Basel). 2020 Apr 19;10(4): - PubMed
  13. Nano Lett. 2019 Nov 13;19(11):7573-7587 - PubMed
  14. Nanomedicine. 2017 Oct;13(7):2325-2328 - PubMed
  15. Soft Matter. 2020 Jun 3;16(21):5032-5043 - PubMed
  16. J Pharm Sci. 2016 Mar;105(3):1113-23 - PubMed
  17. Pharmaceutics. 2019 Dec 03;11(12): - PubMed
  18. Drug Des Devel Ther. 2016 Nov 17;10:3789-3798 - PubMed
  19. Cancers (Basel). 2020 Nov 10;12(11): - PubMed
  20. Langmuir. 2018 Apr 10;34(14):4360-4373 - PubMed
  21. Colloids Surf B Biointerfaces. 2018 Aug 1;168:10-17 - PubMed
  22. J Lipid Res. 2018 Feb;59(2):298-311 - PubMed
  23. Int J Hyperthermia. 2015 Mar;31(2):90-106 - PubMed
  24. EMBO J. 1991 Jul;10(7):1661-9 - PubMed
  25. Int J Pharm. 2011 Aug 30;415(1-2):150-7 - PubMed
  26. Int J Pharm. 2011 Jan 17;403(1-2):292-7 - PubMed
  27. AAPS J. 2015 Jan;17(1):194-205 - PubMed
  28. J Control Release. 2019 Feb 28;296:1-13 - PubMed
  29. J Control Release. 2019 Aug 10;307:331-341 - PubMed
  30. J Cancer Surviv. 2017 Feb;11(1):1-12 - PubMed
  31. Int J Pharm. 2019 Apr 5;560:377-384 - PubMed
  32. Curr Med Chem. 2014;21(3):377-91 - PubMed
  33. Nanomedicine (Lond). 2017 May;12(10):1135-1151 - PubMed
  34. Biotechnol Adv. 2012 Jan-Feb;30(1):302-9 - PubMed
  35. Gastroenterology. 2018 Aug;155(2):282-302.e8 - PubMed
  36. Ultrasound Med Biol. 2020 Jun;46(6):1296-1325 - PubMed
  37. Eur J Pharm Sci. 2017 Oct 15;108:86-92 - PubMed
  38. Front Oncol. 2018 Mar 12;8:49 - PubMed
  39. Ultrasound Med Biol. 2019 Sep;45(9):2575-2582 - PubMed
  40. Langmuir. 2016 Jun 14;32(23):5821-9 - PubMed
  41. Sci Rep. 2016 Feb 25;6:21933 - PubMed
  42. Eur J Pharm Sci. 2015 Dec 1;80:89-110 - PubMed
  43. Expert Opin Drug Deliv. 2018 Sep;15(9):893-903 - PubMed
  44. Eur J Pharm Sci. 2017 Oct 15;108:93-100 - PubMed
  45. Med Devices (Auckl). 2011;4:179-88 - PubMed
  46. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1183-94 - PubMed
  47. Nanoscale. 2018 Oct 21;10(39):18657-18664 - PubMed
  48. FASEB J. 2017 Oct;31(10):4566-4577 - PubMed
  49. Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20 - PubMed
  50. Nano Today. 2015 Jun 1;10(3):397-409 - PubMed
  51. Int J Nanomedicine. 2013;8:1653-63 - PubMed
  52. Eur J Lipid Sci Technol. 2014 Sep;116(9):1088-1107 - PubMed
  53. J Drug Target. 2015;23(7-8):605-18 - PubMed
  54. Soft Matter. 2018 May 16;14(19):3730-3737 - PubMed
  55. Pharm Res. 2013 Feb;30(2):538-51 - PubMed
  56. Eur J Pharm Sci. 2017 Mar 1;99:161-172 - PubMed
  57. Eur J Pharm Sci. 2017 Oct 15;108:101-110 - PubMed
  58. Pharmaceutics. 2020 Aug 12;12(8): - PubMed
  59. J Extracell Vesicles. 2015 Dec 31;4:30087 - PubMed
  60. Biophys J. 2014 Feb 4;106(3):631-8 - PubMed
  61. Anaesthesia. 2019 Oct;74(10):1252-1259 - PubMed
  62. Nanoscale. 2020 Apr 3;12(13):6959-6963 - PubMed
  63. Int J Pharm. 2014 Dec 30;477(1-2):390-8 - PubMed
  64. J Biomed Nanotechnol. 2016 Apr;12(4):811-30 - PubMed
  65. Biophys Chem. 2018 Jul;238:39-48 - PubMed
  66. Nature. 2017 Jun 22;546(7659):498-503 - PubMed
  67. Langmuir. 2020 Mar 31;36(12):3221-3233 - PubMed
  68. Pharm Res. 2010 Aug;27(8):1469-86 - PubMed
  69. J Biomed Res. 2019 Jul 28;33(4):221-234 - PubMed
  70. ACS Nano. 2018 Jul 24;12(7):6830-6842 - PubMed
  71. Front Pharmacol. 2019 Dec 05;10:1463 - PubMed
  72. Int J Mol Sci. 2017 May 04;18(5): - PubMed
  73. Eur J Pharm Sci. 2015 Jul 10;74:11-7 - PubMed
  74. J Pharm Sci. 2013 Aug;102(8):2689-98 - PubMed
  75. AAPS PharmSciTech. 2019 Apr 9;20(4):159 - PubMed
  76. Adv Drug Deliv Rev. 2020;159:180-197 - PubMed
  77. Int J Pharm. 2015 Oct 15;494(1):445-52 - PubMed
  78. Cancer Immunol Res. 2018 Sep;6(9):990-1000 - PubMed
  79. Nutr Res. 2013 Mar;33(3):242-50 - PubMed
  80. Langmuir. 2018 Jan 16;34(2):572-584 - PubMed
  81. Adv Wound Care (New Rochelle). 2016 May 1;5(5):198-207 - PubMed
  82. Adv Sci (Weinh). 2020 Sep 07;7(20):2001675 - PubMed
  83. Pharmaceutics. 2019 Dec 12;11(12): - PubMed
  84. Clin Cancer Res. 2016 Apr 15;22(8):1897-906 - PubMed
  85. Nat Protoc. 2018 May;13(5):856-874 - PubMed
  86. Mol Ther. 2017 Jul 5;25(7):1580-1587 - PubMed
  87. Int J Pharm. 2011 Feb 28;405(1-2):210-7 - PubMed
  88. Nat Rev Neurosci. 2017 May;18(5):281-298 - PubMed
  89. Lab Chip. 2019 Feb 26;19(5):837-844 - PubMed
  90. J Control Release. 2018 Aug 28;284:213-223 - PubMed
  91. Pharmaceutics. 2020 Jun 19;12(6): - PubMed
  92. ACS Nano. 2019 Oct 22;13(10):11008-11021 - PubMed
  93. Pharmaceutics. 2020 Aug 14;12(8): - PubMed
  94. Nat Biotechnol. 2017 Mar;35(3):222-229 - PubMed
  95. Adv Funct Mater. 2017 Mar 17;27(11): - PubMed
  96. Int J Pharm. 2015 Jul 25;490(1-2):391-403 - PubMed
  97. Nanomedicine. 2013 Oct;9(7):1089-97 - PubMed
  98. Chem Pharm Bull (Tokyo). 1985 Feb;33(2):572-82 - PubMed
  99. Mol Pharm. 2012 May 7;9(5):1189-98 - PubMed
  100. Org Biomol Chem. 2018 Apr 18;16(15):2711-2724 - PubMed
  101. J Mater Chem B. 2017 Jun 21;5(23):4348-4364 - PubMed
  102. Molecules. 2009 Dec 22;14(12):5367-81 - PubMed
  103. Nat Commun. 2016 Jan 22;7:10447 - PubMed
  104. Biochim Biophys Acta Gen Subj. 2020 Feb 19;:129559 - PubMed
  105. Prog Lipid Res. 2003 Sep;42(5):423-38 - PubMed
  106. Chem Rev. 2004 Jun;104(6):2901-37 - PubMed
  107. Eur J Pharm Sci. 2017 Nov 15;109:464-471 - PubMed
  108. J Phys Condens Matter. 2009 May 20;21(20):203102 - PubMed
  109. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2546-51 - PubMed
  110. Polymers (Basel). 2017 Nov 03;9(11): - PubMed
  111. Life Sci. 1982 Jun 14;30(24):2123-36 - PubMed
  112. Pharm Biol. 2014 Jul;52(7):883-9 - PubMed
  113. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2222-30 - PubMed
  114. Nanomedicine. 2011 Apr;7(2):153-61 - PubMed
  115. Biomaterials. 2016 Sep;102:231-8 - PubMed
  116. J Chem Phys. 2020 Feb 7;152(5):054707 - PubMed
  117. Pharmacol Rev. 1999 Dec;51(4):691-743 - PubMed
  118. J Control Release. 2012 Jun 10;160(2):117-34 - PubMed
  119. Planta Med. 2019 May;85(7):524-527 - PubMed
  120. J Extracell Vesicles. 2015 May 14;4:27066 - PubMed
  121. Eur J Pharm Biopharm. 2014 Apr;86(3):544-51 - PubMed
  122. Nat Rev Drug Discov. 2016 Apr;15(4):249-74 - PubMed
  123. Eur J Pharm Biopharm. 1998 Nov;46(3):361-7 - PubMed
  124. Biomolecules. 2019 Jul 25;9(8): - PubMed
  125. Cell Death Differ. 2003 Mar;10(3):371-82 - PubMed
  126. J Pharm Sci. 2008 Aug;97(8):2892-923 - PubMed
  127. Pharmaceutics. 2020 Aug 31;12(9): - PubMed
  128. Int J Nanomedicine. 2014 Sep 16;9:4387-98 - PubMed
  129. Eur J Pharm Sci. 2019 Jan 15;127:199-207 - PubMed
  130. PLoS One. 2010 May 03;5(5):e10445 - PubMed
  131. Eur J Pharm Sci. 2020 Apr 30;147:105272 - PubMed
  132. Nat Nanotechnol. 2012 Aug;7(8):536-43 - PubMed
  133. Nat Rev Dis Primers. 2019 Jan 7;5(1):1 - PubMed
  134. Br J Pharmacol. 2007 Jul;151(6):844-50 - PubMed
  135. J Drug Target. 2019 Jun - Jul;27(5-6):681-689 - PubMed
  136. J Extracell Vesicles. 2013 Feb 15;2: - PubMed
  137. Pharm Res. 2015 Jan;32(1):91-102 - PubMed
  138. Eur J Pharm Biopharm. 2016 Jun;103:159-166 - PubMed
  139. Pain Manag. 2018 Sep 1;8(5):313-315 - PubMed
  140. J Colloid Interface Sci. 2016 Dec 15;484:86-96 - PubMed
  141. Curr Med Chem. 2009;16(33):4361-71 - PubMed
  142. Angew Chem Int Ed Engl. 2020 May 25;59(22):8608-8615 - PubMed
  143. J Control Release. 2020 Feb;318:256-263 - PubMed
  144. Biophys Chem. 2019 Jan;244:1-10 - PubMed
  145. Prog Lipid Res. 2005 Jan;44(1):68-97 - PubMed
  146. Cell Rep. 2018 Feb 6;22(6):1484-1495 - PubMed
  147. Nanomedicine. 2020 Jan;23:102096 - PubMed
  148. Langmuir. 2015 Feb 17;31(6):1879-84 - PubMed
  149. Pharm Res. 2006 Sep;23(9):1959-69 - PubMed
  150. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6254-E6263 - PubMed
  151. Adv Drug Deliv Rev. 2014 Jun;72:28-48 - PubMed
  152. Pharmaceutics. 2020 Aug 28;12(9): - PubMed
  153. J Control Release. 2013 Apr 10;167(1):92-100 - PubMed
  154. J Lipid Res. 1977 Jul;18(4):548-52 - PubMed
  155. Nanomedicine. 2005 Sep;1(3):193-212 - PubMed
  156. Eur J Pharm Sci. 2017 Oct 15;108:111-118 - PubMed
  157. J Control Release. 2018 May 10;277:1-13 - PubMed
  158. Int J Nanomedicine. 2014 Jan 15;9:505-15 - PubMed
  159. Int J Pharm. 2020 Apr 30;580:119209 - PubMed
  160. FASEB J. 2018 Feb;32(2):969-978 - PubMed
  161. J Dermatolog Treat. 2015 Oct;26(5):465-70 - PubMed
  162. ACS Nano. 2017 Jan 24;11(1):69-83 - PubMed
  163. Int J Nanomedicine. 2015 Feb 02;10:975-99 - PubMed
  164. J Pharmacol Exp Ther. 2018 Jul;366(1):1-8 - PubMed
  165. Adv Sci (Weinh). 2020 Oct 27;7(23):2002596 - PubMed
  166. Mol Pharm. 2016 Jun 6;13(6):2095-107 - PubMed
  167. Eur J Pharm Sci. 2017 Oct 15;108:1-12 - PubMed

Publication Types