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Pietrocola F, Bravo-San Pedro JM. Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress. Antioxidants (Basel). 2021;10(1)doi: 10.3390/antiox10010102.
Pietrocola, F., & Bravo-San Pedro, J. M. (2021). Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress. Antioxidants (Basel, Switzerland), 10(1), . https://doi.org/10.3390/antiox10010102
Pietrocola, Federico, and Bravo-San Pedro, José Manuel. "Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress." Antioxidants (Basel, Switzerland) vol. 10,1 (2021). doi: https://doi.org/10.3390/antiox10010102
Pietrocola F, Bravo-San Pedro JM. Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress. Antioxidants (Basel). 2021 Jan 12;10(1). doi: 10.3390/antiox10010102. PMID: 33445755; PMCID: PMC7828170.
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Antioxidants (Basel). 2021 Jan 12;10(1). doi: 10.3390/antiox10010102.

Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress.

Antioxidants (Basel, Switzerland)

Federico Pietrocola, José Manuel Bravo-San Pedro

Affiliations

  1. Department of Bioscience and Nutrition, Karolinska Institute, Neo Blickagången 16, 14183 Huddinge, Sweden.
  2. Departamento de Fisiología, Facultad de Medicina, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.

PMID: 33445755 PMCID: PMC7828170 DOI: 10.3390/antiox10010102

Abstract

Reactive oxygen species (ROS) operate as key regulators of cellular homeostasis within a physiological range of concentrations, yet they turn into cytotoxic entities when their levels exceed a threshold limit. Accordingly, ROS are an important etiological cue for obesity, which in turn represents a major risk factor for multiple diseases, including diabetes, cardiovascular disorders, non-alcoholic fatty liver disease, and cancer. Therefore, the implementation of novel therapeutic strategies to improve the obese phenotype by targeting oxidative stress is of great interest for the scientific community. To this end, it is of high importance to shed light on the mechanisms through which cells curtail ROS production or limit their toxic effects, in order to harness them in anti-obesity therapy. In this review, we specifically discuss the role of autophagy in redox biology, focusing on its implication in the pathogenesis of obesity. Because autophagy is specifically triggered in response to redox imbalance as a quintessential cytoprotective mechanism, maneuvers based on the activation of autophagy hold promises of efficacy for the prevention and treatment of obesity and obesity-related morbidities.

Keywords: antioxidants; autophagy; obesity; stress

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