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Teirlinck E, Fraire JC, Van Acker H, et al. Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care. Biofilm. 2019;1:100004doi: 10.1016/j.bioflm.2019.100004.
Teirlinck, E., Fraire, J. C., Van Acker, H., Wille, J., Swimberghe, R., Brans, T., Xiong, R., Meire, M., De Moor, R. J. G., De Smedt, S. C., Coenye, T., & Braeckmans, K. (2019). Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care. Biofilm, 1100004. https://doi.org/10.1016/j.bioflm.2019.100004
Teirlinck, E, et al. "Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care." Biofilm vol. 1 (2019): 100004. doi: https://doi.org/10.1016/j.bioflm.2019.100004
Teirlinck E, Fraire JC, Van Acker H, Wille J, Swimberghe R, Brans T, Xiong R, Meire M, De Moor RJG, De Smedt SC, Coenye T, Braeckmans K. Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care. Biofilm. 2019 Jul 31;1:100004. doi: 10.1016/j.bioflm.2019.100004. eCollection 2019 Dec. PMID: 33447791; PMCID: PMC7798460.
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Biofilm. 2019 Jul 31;1:100004. doi: 10.1016/j.bioflm.2019.100004. eCollection 2019 Dec.

Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care.

Biofilm

E Teirlinck, J C Fraire, H Van Acker, J Wille, R Swimberghe, T Brans, R Xiong, M Meire, R J G De Moor, S C De Smedt, T Coenye, K Braeckmans

Affiliations

  1. Laboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Ghent, 9000, Belgium.
  2. Centre for Nano- and Biophotonics, Ghent, 9000, Belgium.
  3. Laboratory of Pharmaceutical Microbiology, University of Ghent, Ghent, 9000, Belgium.
  4. Department of Oral Health Sciences, Section of Endodontology, University of Ghent, Ghent, 9000, Belgium.
  5. IEMN UMR 8520, Université de Lille, Villeneuve d'Ascq, 59652, France.
  6. Laboratoire de Physique des Lasers, Atomes et Molécules UMR 8523, Villeneuve d'Ascq, 59655, France.

PMID: 33447791 PMCID: PMC7798460 DOI: 10.1016/j.bioflm.2019.100004

Abstract

Being responsible for delayed wound healing, the presence of biofilms in infected wounds leads to chronic, and difficult to treat infections. One of the reasons why antimicrobial treatment often fails to cure biofilm infections is the reduced penetration rate of antibiotics through dense biofilms. Strategies that have the ability to somehow interfere with the integrity of biofilms and allowing a better penetration of drugs are highly sought after. A promising new approach is the use of laser-induced vapor nanobubbles (VNB), of which it was recently demonstrated that it can substantially enhance the penetration of antibiotics into biofilms, resulting in a marked improvement of the killing efficiency. In this study, we examined if treatment of biofilms with laser-induced vapor nanobubbles (VNB) can enhance the potency of antimicrobials which are commonly used to treat wound infections, including povidone-iodine, chlorhexidine, benzalkonium chloride, cetrimonium bromide and mupirocin. Our investigations were performed on

© 2019 Published by Elsevier B.V.

Keywords: Biofilms; Diffusion barrier; Disinfectants; Laser treatment; Vapor nanobubbles; Wound infections

References

  1. Appl Environ Microbiol. 2008 Mar;74(6):1869-75 - PubMed
  2. Microorganisms. 2017 Apr 01;5(2): - PubMed
  3. Antimicrob Agents Chemother. 2019 Mar 27;63(4): - PubMed
  4. Expert Rev Anti Infect Ther. 2015 May;13(5):605-13 - PubMed
  5. Antimicrob Agents Chemother. 2014 Aug;58(8):4353-61 - PubMed
  6. Trends Microbiol. 2014 Jun;22(6):326-33 - PubMed
  7. Wound Repair Regen. 2011 Jan-Feb;19(1):1-9 - PubMed
  8. Recent Pat Antiinfect Drug Discov. 2010 Jan;5(1):10-7 - PubMed
  9. Environ Microbiol. 2013 Oct;15(10):2865-78 - PubMed
  10. ACS Nano. 2014 Jun 24;8(6):6288-96 - PubMed
  11. Nano Lett. 2016 Oct 12;16(10):5975-5986 - PubMed
  12. Int J Surg. 2017 Aug;44:260-268 - PubMed
  13. Antimicrob Agents Chemother. 2017 Nov 22;61(12): - PubMed
  14. Antimicrob Agents Chemother. 2017 Jan 24;61(2): - PubMed
  15. PLoS One. 2013 May 27;8(5):e63750 - PubMed
  16. J Wound Care. 2009 Feb;18(2):54-6 - PubMed
  17. Wound Repair Regen. 2009 Nov-Dec;17(6):763-71 - PubMed
  18. Antimicrob Agents Chemother. 2004 May;48(5):1461-8 - PubMed
  19. Drug Dev Ind Pharm. 2017 Oct;43(10):1715-1728 - PubMed
  20. Nat Rev Microbiol. 2017 Dec;15(12):740-755 - PubMed
  21. Nanomedicine (Lond). 2009 Oct;4(7):813-45 - PubMed
  22. Antimicrob Agents Chemother. 2015;59(6):3350-6 - PubMed
  23. Front Cell Neurosci. 2018 Mar 29;12:80 - PubMed
  24. Curr Pharm Des. 2015;21(1):5-11 - PubMed
  25. ACS Infect Dis. 2015 Jul 10;1(7):288-303 - PubMed
  26. J Dent Res. 2010 Mar;89(3):205-18 - PubMed
  27. Appl Environ Microbiol. 2009 Mar;75(5):1308-14 - PubMed
  28. Nat Commun. 2018 Oct 30;9(1):4518 - PubMed
  29. J Cyst Fibros. 2014 Jan;13(1):56-62 - PubMed
  30. J Endod. 2011 May;37(5):657-61 - PubMed
  31. Wound Repair Regen. 2017 Sep;25(5):744-757 - PubMed
  32. Plast Surg (Oakv). 2017 Feb;25(1):21-26 - PubMed
  33. J Control Release. 2017 Nov 28;266:198-204 - PubMed
  34. J Dent Res. 2005 Dec;84(12):1172-7 - PubMed
  35. Appl Environ Microbiol. 1994 Dec;60(12):4339-44 - PubMed
  36. J Antimicrob Chemother. 2007 Dec;60(6):1281-7 - PubMed
  37. Biotechnol Bioeng. 1998 Aug 5;59(3):261-72 - PubMed
  38. Lab Med. 2015 Fall;46(4):277-84 - PubMed
  39. PLoS One. 2013 Nov 14;8(11):e79220 - PubMed
  40. J Bacteriol. 2003 Mar;185(5):1485-91 - PubMed
  41. Dermatology. 2017;233(2-3):223-233 - PubMed
  42. Int Wound J. 2010 Jun;7(3):169-75 - PubMed
  43. Adv Ther. 2017 Mar;34(3):599-610 - PubMed
  44. Sci Rep. 2016 Jun 21;6:27537 - PubMed
  45. J Control Release. 2014 Dec 10;195:21-8 - PubMed
  46. Antimicrob Agents Chemother. 2002 May;46(5):1469-74 - PubMed
  47. FEMS Microbiol Ecol. 2013 Jan;83(1):101-11 - PubMed
  48. IEEE Trans Biomed Eng. 2017 Apr;64(4):882-889 - PubMed
  49. Surg Clin North Am. 1997 Jun;77(3):637-50 - PubMed
  50. J Wound Care. 2018 May 2;27(5):273-277 - PubMed
  51. Sci Rep. 2015 Dec 10;5:17440 - PubMed
  52. Antimicrob Agents Chemother. 2011 Jun;55(6):2648-54 - PubMed
  53. Biofouling. 2011 Oct;27(9):1017-32 - PubMed
  54. Sci Rep. 2018 Jul 16;8(1):10738 - PubMed
  55. Microbiol Insights. 2014 Mar 05;7:9-13 - PubMed
  56. Antimicrob Agents Chemother. 2011 Jul;55(7):3338-44 - PubMed
  57. Clin Cosmet Investig Dermatol. 2016 Feb 04;9:29-40 - PubMed
  58. Macromol Biosci. 2016 Jun;16(6):859-69 - PubMed
  59. Wound Repair Regen. 2008 Jan-Feb;16(1):2-10 - PubMed
  60. PLoS One. 2011;6(11):e27317 - PubMed

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