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Maiti S, Manna S, Banahene N, et al. From Glucose to Polymers: A Continuous Chemoenzymatic Process. Angew Chem Int Ed Engl. 2020;59(43):18943-18947doi: 10.1002/anie.202006468.
Maiti, S., Manna, S., Banahene, N., Pham, L., Liang, Z., Wang, J., Xu, Y., Bettinger, R., Zientko, J., Esser-Kahn, A. P., & Du, W. (2020). From Glucose to Polymers: A Continuous Chemoenzymatic Process. Angewandte Chemie (International ed. in English), 59(43), 18943-18947. https://doi.org/10.1002/anie.202006468
Maiti, Sampa, et al. "From Glucose to Polymers: A Continuous Chemoenzymatic Process." Angewandte Chemie (International ed. in English) vol. 59,43 (2020): 18943-18947. doi: https://doi.org/10.1002/anie.202006468
Maiti S, Manna S, Banahene N, Pham L, Liang Z, Wang J, Xu Y, Bettinger R, Zientko J, Esser-Kahn AP, Du W. From Glucose to Polymers: A Continuous Chemoenzymatic Process. Angew Chem Int Ed Engl. 2020 Oct 19;59(43):18943-18947. doi: 10.1002/anie.202006468. Epub 2020 Aug 20. PMID: 33448568.
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Angew Chem Int Ed Engl. 2020 Oct 19;59(43):18943-18947. doi: 10.1002/anie.202006468. Epub 2020 Aug 20.

From Glucose to Polymers: A Continuous Chemoenzymatic Process.

Angewandte Chemie (International ed. in English)

Sampa Maiti, Saikat Manna, Nicholas Banahene, Lucynda Pham, Zhijie Liang, Jun Wang, Yi Xu, Reuben Bettinger, John Zientko, Aaron P Esser-Kahn, Wenjun Du

Affiliations

  1. Department of Chemistry and Biochemistry, Science of Advanced Materials, Central Michigan University, Mount Pleasant, MI, 48859, USA.
  2. Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.
  3. Current address: Department of Wound Repair Surgery, The Fifth Affiliated Hospital of Guangxi Medical University & The First People's Hospital of Nanning, Nanning, 530000, China.

PMID: 33448568 DOI: 10.1002/anie.202006468

Abstract

Efforts to synthesize degradable polymers from renewable resources are deterred by technical and economic challenges; especially, the conversion of natural building blocks into polymerizable monomers is inefficient, requiring multistep synthesis and chromatographic purification. Herein we report a chemoenzymatic process to address these challenges. An enzymatic reaction system was designed that allows for regioselective functional group transformation, efficiently converting glucose into a polymerizable monomer in quantitative yield, thus removing the need for chromatographic purification. With this key success, we further designed a continuous, three-step process, which enabled the synthesis of a sugar polymer, sugar poly(orthoester), directly from glucose in high yield (73 % from glucose). This work may provide a proof-of-concept in developing technically and economically viable approaches to address the many issues associated with current petroleum-based polymers.

© 2020 Wiley‐VCH GmbH.

Keywords: chemoenzymatic processes; glucose; poly(orthoester); polymer synthesis; sustainable chemistry

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