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Nozawa T, Mihara-Tomiyama N, Chiba T, et al. NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells. Biochem Biophys Res Commun. 2021;542:24-28doi: 10.1016/j.bbrc.2021.01.025.
Nozawa, T., Mihara-Tomiyama, N., Chiba, T., & Imai, K. (2021). NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells. Biochemical and biophysical research communications, 54224-28. https://doi.org/10.1016/j.bbrc.2021.01.025
Nozawa, Takaomi, et al. "NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells." Biochemical and biophysical research communications vol. 542 (2021): 24-28. doi: https://doi.org/10.1016/j.bbrc.2021.01.025
Nozawa T, Mihara-Tomiyama N, Chiba T, Imai K. NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells. Biochem Biophys Res Commun. 2021 Jan 19;542:24-28. doi: 10.1016/j.bbrc.2021.01.025. Epub 2021 Jan 19. PMID: 33482470.
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Biochem Biophys Res Commun. 2021 Jan 19;542:24-28. doi: 10.1016/j.bbrc.2021.01.025. Epub 2021 Jan 19.

NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells.

Biochemical and biophysical research communications

Takaomi Nozawa, Nozomi Mihara-Tomiyama, Tadashige Chiba, Kazushi Imai

Affiliations

  1. Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo, 102-8159, Japan.
  2. Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo, 102-8159, Japan. Electronic address: [email protected].

PMID: 33482470 DOI: 10.1016/j.bbrc.2021.01.025

Abstract

Loss of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) expression closely associates with increased aggressive behaviors of oral carcinoma cells. It emphasizes that a mechanism to suppress the expression is an important subject for understanding carcinoma progression pathway. However, nothing is known at present. This study conducted on transcriptional regulation of the gene down-regulation. Reporter assays showed the presence of the silencer region between +402 and +501 region of MALT1 gene in oral carcinoma cells. It encoded a binding site of nuclear factor-κB subunit, RELA. RELA binding to the site was confirmed by the chromatin immunoprecipitation analyses, and deletion and mutations of the site significantly decreased the RELA binding. Short interfering RNAs for RELA up-regulated reporter gene and endogenous MALT1 protein expressions, and deletion and mutations of RELA binding site increased reporter gene expression. These results demonstrated RELA-binding to the site suppresses MALT1 expression that may facilitate oral carcinoma progression.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Mucosa-associated lymphoid tissue lymphoma translocation protein 1; NF-κB; Oral carcinoma; Repressor proteins

Conflict of interest statement

Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial of financial relationship that could be considered as a potential conflict of int

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