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Hoque MR, Aviña-Zubieta JA, De Vera MA, et al. Impact of Antimalarial Adherence on Mortality among Patients with Newly Diagnosed Systemic Lupus Erythematosus: A Population-based Cohort Study. Arthritis Care Res (Hoboken). 2021;doi: 10.1002/acr.24550.
Hoque, M. R., Aviña-Zubieta, J. A., De Vera, M. A., Qian, Y., Esdaile, J. M., & Xie, H. (2021). Impact of Antimalarial Adherence on Mortality among Patients with Newly Diagnosed Systemic Lupus Erythematosus: A Population-based Cohort Study. Arthritis care & research, . https://doi.org/10.1002/acr.24550
Hoque, M Rashedul, et al. "Impact of Antimalarial Adherence on Mortality among Patients with Newly Diagnosed Systemic Lupus Erythematosus: A Population-based Cohort Study." Arthritis care & research vol. (2021). doi: https://doi.org/10.1002/acr.24550
Hoque MR, Aviña-Zubieta JA, De Vera MA, Qian Y, Esdaile JM, Xie H. Impact of Antimalarial Adherence on Mortality among Patients with Newly Diagnosed Systemic Lupus Erythematosus: A Population-based Cohort Study. Arthritis Care Res (Hoboken). 2021 Jan 07; doi: 10.1002/acr.24550. Epub 2021 Jan 07. PMID: 33411964.
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Arthritis Care Res (Hoboken). 2021 Jan 07; doi: 10.1002/acr.24550. Epub 2021 Jan 07.

Impact of Antimalarial Adherence on Mortality among Patients with Newly Diagnosed Systemic Lupus Erythematosus: A Population-based Cohort Study.

Arthritis care & research

M Rashedul Hoque, J Antonio Aviña-Zubieta, Mary A De Vera, Yi Qian, John M Esdaile, Hui Xie

Affiliations

  1. Arthritis Research Canada, Richmond, Canada, British Columbia.
  2. Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada, British Columbia.
  3. Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, Canada.
  4. Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
  5. Sauder School of Business, University of British Columbia, Vancouver, Canada.

PMID: 33411964 DOI: 10.1002/acr.24550

Abstract

OBJECTIVE: To assess the association of antimalarials (AM) adherence with premature mortality among incident systemic lupus erythematosus (SLE) patients.

METHODS: All patients with incident SLE and incident AM use in British Columbia, Canada, between January 1997 and March 2015 were identified using the provincial administrative databases. Follow-up started on the first day of having both SLE and AM. The outcome was all-cause mortality. An adherence measure, proportion of days covered (PDC), was calculated and categorized as adherent (PDC≥0.90), non-adherent (0

RESULTS: We identified 3,062 individuals with incident SLE and incident AM use (mean age 46.9 years). Over the mean follow-up of 6.4 years, 242 (7.9%) of them died. Adjusted hazard ratios (aHRs) from Cox's model for AM adherent and non-adherent SLE patients were 0.20 (95% CI:0.13-0.29) and 0.62 (95% CI:0.42-0.91), respectively, compared to discontinuers. The corresponding aHRs from the marginal structural Cox model were 0.17 (95% CI:0.12-0.25) and 0.58 (95% CI:0.40-0.85), respectively. A significant trend in the aHRs of mortality risk over the adherence levels was found (p-value:<0.001).

CONCLUSION: SLE patients adhering to AM therapy had a 71% and 83% lower risk of death than patients who do not adhere or who discontinue AM, respectively.

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