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Shchelkunov SN, Yakubitskiy SN, Bauer TV, et al. The Influence of an Elevated Production of Extracellular Enveloped Virions of the Vaccinia Virus on Its Properties in Infected Mice. Acta Naturae. 2020;12(4):120-132doi: 10.32607/actanaturae.10972.
Shchelkunov, S. N., Yakubitskiy, S. N., Bauer, T. V., Sergeev, A. A., Kabanov, A. S., Bulichev, L. E., Yurganova, I. A., Odnoshevskiy, D. A., Kolosova, I. V., Pyankov, S. A., & Taranov, O. S. (2020). The Influence of an Elevated Production of Extracellular Enveloped Virions of the Vaccinia Virus on Its Properties in Infected Mice. Acta naturae, 12(4), 120-132. https://doi.org/10.32607/actanaturae.10972
Shchelkunov, S N, et al. "The Influence of an Elevated Production of Extracellular Enveloped Virions of the Vaccinia Virus on Its Properties in Infected Mice." Acta naturae vol. 12,4 (2020): 120-132. doi: https://doi.org/10.32607/actanaturae.10972
Shchelkunov SN, Yakubitskiy SN, Bauer TV, Sergeev AA, Kabanov AS, Bulichev LE, Yurganova IA, Odnoshevskiy DA, Kolosova IV, Pyankov SA, Taranov OS. The Influence of an Elevated Production of Extracellular Enveloped Virions of the Vaccinia Virus on Its Properties in Infected Mice. Acta Naturae. 2020 Oct-Dec;12(4):120-132. doi: 10.32607/actanaturae.10972. PMID: 33456984; PMCID: PMC7800600.
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Acta Naturae. 2020 Oct-Dec;12(4):120-132. doi: 10.32607/actanaturae.10972.

The Influence of an Elevated Production of Extracellular Enveloped Virions of the Vaccinia Virus on Its Properties in Infected Mice.

Acta naturae

S N Shchelkunov, S N Yakubitskiy, T V Bauer, A A Sergeev, A S Kabanov, L E Bulichev, I A Yurganova, D A Odnoshevskiy, I V Kolosova, S A Pyankov, O S Taranov

Affiliations

  1. State Research Center of Virology and Biotechnology VECTOR, Rospoterbnadzor, Novosibirsk region, Koltsovo, 630559 Russia.

PMID: 33456984 PMCID: PMC7800600 DOI: 10.32607/actanaturae.10972

Abstract

The modern approach to developing attenuated smallpox vaccines usually consists in targeted inactivation of vaccinia virus (VACV) virulence genes. In this work, we studied how an elevated production of extracellular enveloped virions (EEVs) and the route of mouse infection can influence the virulence and immunogenicity of VACV. The research subject was the LIVP strain, which is used in Russia for smallpox vaccination. Two point mutations causing an elevated production of EEVs compared with the parental LIVP strain were inserted into the sequence of the VACV

Copyright ® 2020 National Research University Higher School of Economics.

Keywords: immunogenicity; smallpox; vaccine; virulence

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