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Jiménez-Torres C, El-Kehdy H, Hernández-Kelly LC, et al. Acute Liver Toxicity Modifies Protein Expression of Glutamate Transporters in Liver and Cerebellar Tissue. Front Neurosci. 2021;14:613225doi: 10.3389/fnins.2020.613225.
Jiménez-Torres, C., El-Kehdy, H., Hernández-Kelly, L. C., Sokal, E., Ortega, A., & Najimi, M. (2020). Acute Liver Toxicity Modifies Protein Expression of Glutamate Transporters in Liver and Cerebellar Tissue. Frontiers in neuroscience, 14613225. https://doi.org/10.3389/fnins.2020.613225
Jiménez-Torres, Catya, et al. "Acute Liver Toxicity Modifies Protein Expression of Glutamate Transporters in Liver and Cerebellar Tissue." Frontiers in neuroscience vol. 14 (2020): 613225. doi: https://doi.org/10.3389/fnins.2020.613225
Jiménez-Torres C, El-Kehdy H, Hernández-Kelly LC, Sokal E, Ortega A, Najimi M. Acute Liver Toxicity Modifies Protein Expression of Glutamate Transporters in Liver and Cerebellar Tissue. Front Neurosci. 2021 Jan 06;14:613225. doi: 10.3389/fnins.2020.613225. eCollection 2020. PMID: 33488353; PMCID: PMC7815688.
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Front Neurosci. 2021 Jan 06;14:613225. doi: 10.3389/fnins.2020.613225. eCollection 2020.

Acute Liver Toxicity Modifies Protein Expression of Glutamate Transporters in Liver and Cerebellar Tissue.

Frontiers in neuroscience

Catya Jiménez-Torres, Hoda El-Kehdy, Luisa C Hernández-Kelly, Etienne Sokal, Arturo Ortega, Mustapha Najimi

Affiliations

  1. Laboratorio de Neurotoxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Departamento de Toxicología, Mexico City, Mexico.
  2. Laboratory of Pediatric Hepatology and Cell Therapy, UCLouvain, Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium.

PMID: 33488353 PMCID: PMC7815688 DOI: 10.3389/fnins.2020.613225

Abstract

Glutamate is the main excitatory amino acid acting at the level of pre and postsynaptic neurons, as well as in glial cells. It is involved in the coordinated modulation of energy metabolism, glutamine synthesis, and ammonia detoxification. The relationship between the functional status of liver and brain has been known for many years. The most widely recognized aspect of this relation is the brain dysfunction caused by acute liver injury that manifests a wide spectrum of neurologic and psychiatric abnormalities. Inflammation, circulating neurotoxins, and impaired neurotransmission have been reported in this pathophysiology. In the present contribution, we report the effect of a hepatotoxic compound like CCl

Copyright © 2021 Jiménez-Torres, El-Kehdy, Hernández-Kelly, Sokal, Ortega and Najimi.

Keywords: GLAST/EAAT1; GLT1/EAAT2; carbon tetrachloride; glial cell; glutamine synthetase; liver injury

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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