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Pizoń T, Rajzer M, Wojciechowska W, et al. Plasma renin activity, serum aldosterone concentration and selected organ damage indices in essential arterial hypertension. Arch Med Sci. 2018;17(1):9-18doi: 10.5114/aoms.2018.73333.
Pizoń, T., Rajzer, M., Wojciechowska, W., Drożdż, T., Drożdż, D., Rojek, M., Gruszka, K., & Czarnecka, D. (2021). Plasma renin activity, serum aldosterone concentration and selected organ damage indices in essential arterial hypertension. Archives of medical science : AMS, 17(1), 9-18. https://doi.org/10.5114/aoms.2018.73333
Pizoń, Tomasz, et al. "Plasma renin activity, serum aldosterone concentration and selected organ damage indices in essential arterial hypertension." Archives of medical science : AMS vol. 17,1 (2021): 9-18. doi: https://doi.org/10.5114/aoms.2018.73333
Pizoń T, Rajzer M, Wojciechowska W, Drożdż T, Drożdż D, Rojek M, Gruszka K, Czarnecka D. Plasma renin activity, serum aldosterone concentration and selected organ damage indices in essential arterial hypertension. Arch Med Sci. 2018 Feb 07;17(1):9-18. doi: 10.5114/aoms.2018.73333. eCollection 2021. PMID: 33488850; PMCID: PMC7811306.
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Arch Med Sci. 2018 Feb 07;17(1):9-18. doi: 10.5114/aoms.2018.73333. eCollection 2021.

Plasma renin activity, serum aldosterone concentration and selected organ damage indices in essential arterial hypertension.

Archives of medical science : AMS

Tomasz Pizoń, Marek Rajzer, Wiktoria Wojciechowska, Tomasz Drożdż, Dorota Drożdż, Marta Rojek, Krystian Gruszka, Danuta Czarnecka

Affiliations

  1. 1 Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Krakow, Poland.
  2. Department of Pediatric Nephrology, Jagiellonian University Medical College, Krakow, Poland.

PMID: 33488850 PMCID: PMC7811306 DOI: 10.5114/aoms.2018.73333

Abstract

INTRODUCTION: The aim of this study was to assess the relations between plasma renin activity (PRA), serum aldosterone concentration (ALDO) and selected asymptomatic organ damage (AOD) indices in mild primary arterial hypertension (AH).

MATERIAL AND METHODS: We measured PRA, ALDO, and selected AOD indices (carotid-femoral pulse wave velocity (cfPWV), central aortic pulse pressure (cPP), estimated glomerular filtration rate (eGFR)) in 122 patients with untreated AH.

RESULTS: Patients with high PRA (≥ 0.65 ng/ml/h) were characterized by lower plasma sodium and aldosterone to renin ratio (ARR), higher ALDO, but a similar level of AOD indices compared to patients with low PRA. cfPWV (

CONCLUSIONS: Assessment of the influence of the renin-angiotensin-aldosterone system (RAAS) on AOD should include the relationship between renin and aldosterone. The PRA itself has no predictive value for AOD. More advanced arterial stiffness and renal impairment are associated with increased PRA and ARR. The RAAS activity might be useful in AOD prediction and hypertension severity assessment.

Copyright: © 2018 Termedia & Banach.

Keywords: aldosterone; asymptomatic organ damage; essential arterial hypertension; plasma renin activity; renin-angiotensin-aldosterone system

Conflict of interest statement

The authors declare no conflict of interest.

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