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Lucas SJE, Malein WL, Thomas OD, et al. Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m). BMJ Open Sport Exerc Med. 2021;7(1):e000982doi: 10.1136/bmjsem-2020-000982.
Lucas, S. J. E., Malein, W. L., Thomas, O. D., Ashdown, K. M., Rue, C. A., Joyce, K. E., Newman, C., Cadigan, P., Johnson, B., Myers, S. D., Myers, F. A., Wright, A. D., Delamere, J., Imray, C. H. E., Bradwell, A. R., Edsell, M. (2021). Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m). BMJ open sport & exercise medicine, 7(1), e000982. https://doi.org/10.1136/bmjsem-2020-000982
Lucas, Samuel J E, et al. "Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m)." BMJ open sport & exercise medicine vol. 7,1 (2021): e000982. doi: https://doi.org/10.1136/bmjsem-2020-000982
Lucas SJE, Malein WL, Thomas OD, Ashdown KM, Rue CA, Joyce KE, Newman C, Cadigan P, Johnson B, Myers SD, Myers FA, Wright AD, Delamere J, Imray CHE, Bradwell AR, Edsell M. Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m). BMJ Open Sport Exerc Med. 2021 Jan 07;7(1):e000982. doi: 10.1136/bmjsem-2020-000982. eCollection 2021. PMID: 33489310; PMCID: PMC7797254.
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BMJ Open Sport Exerc Med. 2021 Jan 07;7(1):e000982. doi: 10.1136/bmjsem-2020-000982. eCollection 2021.

Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m).

BMJ open sport & exercise medicine

Samuel J E Lucas, William L Malein, Owen D Thomas, Kimberly M Ashdown, Carla A Rue, Kelsey E Joyce, Charles Newman, Patrick Cadigan, Brian Johnson, Stephen D Myers, Fiona A Myers, Alexander D Wright, John Delamere, Chris H E Imray, Arthur R Bradwell, Mark Edsell,

Affiliations

  1. School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
  2. Department of Anaesthesia, Ninewells Hospital, Dundee, UK.
  3. Department of Anaesthesia, Royal Gwent Hospital, Aneurin Bevan University Health Board, Newport, UK.
  4. Occupational Performance Research Group, University of Chichester, Chichester, West Sussex, UK.
  5. Royal Centre for Defence Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
  6. Birmingham Medical Research Expeditionary Society, Birmingham, UK.
  7. School of Biological Sciences, University of Portsmouth, Portsmouth, Hampshire, UK.
  8. School of Medicine, University of Birmingham, Birmingham, UK.
  9. Department of Vascular Surgery, University Hospitals of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK.
  10. Department of Anaesthesia, St George's University Hospitals NHS Foundation Trust, London, UK.

PMID: 33489310 PMCID: PMC7797254 DOI: 10.1136/bmjsem-2020-000982

Abstract

OBJECTIVE: Altitude-related and exercise-related elevations in blood pressure (BP) increase the likelihood of developing pulmonary hypertension and high-altitude illness during high-altitude sojourn. This study examined the antihypertensive effect and potential exercise benefit of the angiotensin II receptor antagonist losartan when taken at altitude.

METHODS: Twenty participants, paired for age and ACE genotype status, completed a double-blinded, randomised study, where participants took either losartan (100 mg/day) or placebo for 21 days prior to arrival at 5035 m (Whymper Hut, Mt Chimborazo, Ecuador). Participants completed a maximal exercise test on a supine cycle ergometer at sea level (4 weeks prior) and within 48 hours of arrival to 5035 m (10-day ascent). Power output, beat-to-beat BP, oxygen saturation (SpO

RESULTS: At altitude, peak power was reduced relative to sea level (p<0.01) in both groups (losartan vs placebo: down 100±29 vs 91±28 W, p=0.55), while SpO

CONCLUSION: Losartan had no observable effect on resting or exercising BP, exercise-induced symptomology of pulmonary hypertension or performance at 5035 m.

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

Keywords: altitude; cardiovascular; exercise; pulmonary

Conflict of interest statement

Competing interests: None declared.

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