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Kikuchi H, Harata K, Madhyastha H, et al. Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-. Biochem Biophys Rep. 2021;25:100891doi: 10.1016/j.bbrep.2020.100891.
Kikuchi, H., Harata, K., Madhyastha, H., & Kuribayashi, F. (2021). Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-. Biochemistry and biophysics reports, 25100891. https://doi.org/10.1016/j.bbrep.2020.100891
Kikuchi, Hidehiko, et al. "Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-." Biochemistry and biophysics reports vol. 25 (2021): 100891. doi: https://doi.org/10.1016/j.bbrep.2020.100891
Kikuchi H, Harata K, Madhyastha H, Kuribayashi F. Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-. Biochem Biophys Rep. 2021 Jan 06;25:100891. doi: 10.1016/j.bbrep.2020.100891. eCollection 2021 Mar. PMID: 33490645; PMCID: PMC7806786.
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Biochem Biophys Rep. 2021 Jan 06;25:100891. doi: 10.1016/j.bbrep.2020.100891. eCollection 2021 Mar.

Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-.

Biochemistry and biophysics reports

Hidehiko Kikuchi, Kaori Harata, Harishkumar Madhyastha, Futoshi Kuribayashi

Affiliations

  1. Department of Food and Nutrition, Shokei University Junior College, 2-6-78 Kuhonji, Chuo-ku, Kumamoto, 862-8678, Japan.
  2. Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, 5200, Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
  3. Department of Biochemistry, Kawasaki Medical School, Kurashiki, Okayama, 701-0192, Japan.

PMID: 33490645 PMCID: PMC7806786 DOI: 10.1016/j.bbrep.2020.100891

Abstract

Ellagitannins (esters composed of glucose and ellagic acid) are hydrolyzed to generate ellagic acid in gut followed by conversion of ellagic acid to urolithins such as urolithin A by intestinal bacteria. Since urolithins are absorbed by gut easier than ellagitannins and ellagic acid, and show various physiological activities (e.g. anti-cancer, anti-cardiovascular disease, anti-diabetes mellitus, anti-obesity and anti-Alzheimer disease activities), they are expected as excellent health-promoting phytochemicals. Here, using human monoblast U937 cells, we investigated the effect of ellagic acid and urolithin A on the superoxide anion (O

© 2021 The Authors.

Keywords: ATRA, all-trans retinoic acid; All-trans retinoic acid; ChIP, chromatin immunoprecipitation; Ellagic acid; H3K14, Lys-14 residues of histone H3; H3K9, Lys-9 residues of histone H3; O2−, superoxide anion; PMA, phorbol 12-myristate 13-acetate; Superoxide; U937; Urolithin A; gp91-phox

Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This work was supported in part by JSPS KAKENHI Grant Number 19K0

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