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Khamaysi I, Hajj E. Drug-induced Pancreatic Atrophy ("The Vanishing Pancreas"). Euroasian J Hepatogastroenterol. 2020;10(2):101-102doi: 10.5005/jp-journals-10018-1323.
Khamaysi, I., & Hajj, E. (2020). Drug-induced Pancreatic Atrophy ("The Vanishing Pancreas"). Euroasian journal of hepato-gastroenterology, 10(2), 101-102. https://doi.org/10.5005/jp-journals-10018-1323
Khamaysi, Iyad, and Hajj, Eisa. "Drug-induced Pancreatic Atrophy ("The Vanishing Pancreas")." Euroasian journal of hepato-gastroenterology vol. 10,2 (2020): 101-102. doi: https://doi.org/10.5005/jp-journals-10018-1323
Khamaysi I, Hajj E. Drug-induced Pancreatic Atrophy ("The Vanishing Pancreas"). Euroasian J Hepatogastroenterol. 2020 Jul-Dec;10(2):101-102. doi: 10.5005/jp-journals-10018-1323. PMID: 33511073; PMCID: PMC7801894.
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Euroasian J Hepatogastroenterol. 2020 Jul-Dec;10(2):101-102. doi: 10.5005/jp-journals-10018-1323.

Drug-induced Pancreatic Atrophy ("The Vanishing Pancreas").

Euroasian journal of hepato-gastroenterology

Iyad Khamaysi, Eisa Hajj

Affiliations

  1. The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
  2. Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.

PMID: 33511073 PMCID: PMC7801894 DOI: 10.5005/jp-journals-10018-1323

Abstract

Immune checkpoint inhibitors have become the therapeutic mainstay in a rapidly growing number of cancers. Immune checkpoint inhibitor-related diarrhea is attributed mainly to inflammatory colitis, with no other drug-related differential diagnosis. However, other causes of diarrhea should be considered. Pancreatic atrophy (and exocrine pancreatic insufficiency) is a relatively rare complication of immune checkpoint inhibitors. Herein we bring a set of striking computed tomography (CT) images that demonstrate a drug-related-progressive pancreatic atrophy until complete vanishing of pancreatic tissue. Exocrine pancreatic insufficiency (EPI) was diagnosed. Pancreatic enzyme replacement therapy was initiated with an excellent clinical response.

Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.

Keywords: Atrophy; Chemotherapy; Pancreas

Conflict of interest statement

Source of support: Nil Conflict of interest: None of the authors has a COI to declare. This manuscript has not been presented before

References

  1. Nat Rev Cancer. 2012 Mar 22;12(4):252-64 - PubMed
  2. Ann Oncol. 2016 Apr;27(4):559-74 - PubMed
  3. Cancer Immunol Res. 2018 Dec;6(12):1453-1458 - PubMed

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