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Chakravarthy R, Stallings SC, Velez Edwards DR, et al. Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors. J Public Health (Oxf). 2021;doi: 10.1093/pubmed/fdaa246.
Chakravarthy, R., Stallings, S. C., Velez Edwards, D. R., Zhao, S. K., Conway, D., Rao, J. S., Aldrich, M. C., Kobetz, E., & Wilkins, C. H. (2021). Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors. Journal of public health (Oxford, England), . https://doi.org/10.1093/pubmed/fdaa246
Chakravarthy, Rohini, et al. "Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors." Journal of public health (Oxford, England) vol. (2021). doi: https://doi.org/10.1093/pubmed/fdaa246
Chakravarthy R, Stallings SC, Velez Edwards DR, Zhao SK, Conway D, Rao JS, Aldrich MC, Kobetz E, Wilkins CH. Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors. J Public Health (Oxf). 2021 Jan 29; doi: 10.1093/pubmed/fdaa246. Epub 2021 Jan 29. PMID: 33512511.
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J Public Health (Oxf). 2021 Jan 29; doi: 10.1093/pubmed/fdaa246. Epub 2021 Jan 29.

Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors.

Journal of public health (Oxford, England)

Rohini Chakravarthy, Sarah C Stallings, Digna R Velez Edwards, Sifang Kathy Zhao, Douglas Conway, J Sunil Rao, Melinda C Aldrich, Erin Kobetz, Consuelo H Wilkins

Affiliations

  1. Vanderbilt University School of Medicine, Nashville, TN, USA.
  2. Department of Medicine, Division of Geriatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  3. Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
  4. Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
  5. Institute for Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
  6. Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  7. Department of Public Health Sciences, University of Miami School of Medicine, Miami, FL, USA.
  8. Division of Biostatistics, University of Miami School of Medicine, Miami, FL, USA.
  9. Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  10. Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
  11. Department of Medicine, University of Miami, Coral Gables, FL, USA.
  12. Meharry-Vanderbilt Alliance, Nashville, TN, USA.
  13. Office of Health Equity, Vanderbilt University Medical Center, Nashville, TN, USA.

PMID: 33512511 DOI: 10.1093/pubmed/fdaa246

Abstract

BACKGROUND: Collecting social determinants of health in electronic health records is time-consuming. Meanwhile, an Area Deprivation Index (ADI) aggregates sociodemographic information from census data. The objective of this study was to ascertain whether ADI is associated with stage of human papillomavirus (HPV)-related cancer at diagnosis.

METHODS: We tested for the association between the stage of HPV-related cancer presentation and ADI as well as the association between stage and the value of each census-based measure using ordered logistic regression, adjusting for age, race and sex.

RESULTS: Among 3247 cases of HPV-related cancers presenting to an urban academic medical center, the average age at diagnosis was 57. The average stage at diagnosis was Surveillance, Epidemiology and End Results Stage 3. In the study population, 43% of patients were female and 87% were white. In this study population, there was no association between stage of HPV-related cancer presentation and either aggregate or individual census variables.

CONCLUSIONS: These results may reflect insufficient sample size, a lack of socio-demographic diversity in our population, or suggest that simplifying social determinants of health into a single geocoded index is not a reliable surrogate for assessing a patient's risk for HPV-related cancer.

© The Author(s) 2021. Published by Oxford University Press on behalf of Faculty of Public Health.

Keywords: cancer; race; social determinants

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