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Dalton T, Greßies S, Das M, et al. Silver-Catalysed Hydroarylation of Highly Substituted Styrenes. Angew Chem Int Ed Engl. 2021;60(15):8537-8541doi: 10.1002/anie.202016268.
Dalton, T., Greßies, S., Das, M., Niehues, M., Schrader, M. L., Gutheil, C., Ravoo, B. J., & Glorius, F. (2021). Silver-Catalysed Hydroarylation of Highly Substituted Styrenes. Angewandte Chemie (International ed. in English), 60(15), 8537-8541. https://doi.org/10.1002/anie.202016268
Dalton, Toryn, et al. "Silver-Catalysed Hydroarylation of Highly Substituted Styrenes." Angewandte Chemie (International ed. in English) vol. 60,15 (2021): 8537-8541. doi: https://doi.org/10.1002/anie.202016268
Dalton T, Greßies S, Das M, Niehues M, Schrader ML, Gutheil C, Ravoo BJ, Glorius F. Silver-Catalysed Hydroarylation of Highly Substituted Styrenes. Angew Chem Int Ed Engl. 2021 Apr 06;60(15):8537-8541. doi: 10.1002/anie.202016268. Epub 2021 Mar 05. PMID: 33493358.
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Angew Chem Int Ed Engl. 2021 Apr 06;60(15):8537-8541. doi: 10.1002/anie.202016268. Epub 2021 Mar 05.

Silver-Catalysed Hydroarylation of Highly Substituted Styrenes.

Angewandte Chemie (International ed. in English)

Toryn Dalton, Steffen Greßies, Mowpriya Das, Maximilian Niehues, Malte L Schrader, Christian Gutheil, Bart Jan Ravoo, Frank Glorius

Affiliations

  1. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.

PMID: 33493358 DOI: 10.1002/anie.202016268

Abstract

Hydroarylation is an effective strategy to rapidly increase the complexity of organic structures by transforming flat alkene moieties into three-dimensional frameworks. Many strategies have already been developed to achieve the hydroarylation of styrenes, however most of these reports examine the hydroarylation of unpolar, β-mono- or β-unsubstituted styrenes, while exploring mainly electron-rich benzene nucleophiles. Herein, we report a mild and general catalytic system for the selective hydroheteroarylation of multiply substituted styrenes and heteroaromatic styrenes. Mechanistic analysis of the reaction led to the discovery of commercially available 2,2':5',2''-terthiophene as a key reagent.

© 2021 Wiley-VCH GmbH.

Keywords: catalysis; heteroarenes; hydroarylation; silver; styrenes

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