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Buitrago-Molina LE, Dywicki J, Noyan F, et al. Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis. Biomedicines. 2021;9(1)doi: 10.3390/biomedicines9010058.
Buitrago-Molina, L. E., Dywicki, J., Noyan, F., Trippler, M., Pietrek, J., Schlue, J., Manns, M. P., Wedemeyer, H., Jaeckel, E., & Hardtke-Wolenski, M. (2021). Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis. Biomedicines, 9(1), . https://doi.org/10.3390/biomedicines9010058
Buitrago-Molina, Laura Elisa, et al. "Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis." Biomedicines vol. 9,1 (2021). doi: https://doi.org/10.3390/biomedicines9010058
Buitrago-Molina LE, Dywicki J, Noyan F, Trippler M, Pietrek J, Schlue J, Manns MP, Wedemeyer H, Jaeckel E, Hardtke-Wolenski M. Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis. Biomedicines. 2021 Jan 09;9(1). doi: 10.3390/biomedicines9010058. PMID: 33435354; PMCID: PMC7827897.
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Biomedicines. 2021 Jan 09;9(1). doi: 10.3390/biomedicines9010058.

Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis.

Biomedicines

Laura Elisa Buitrago-Molina, Janine Dywicki, Fatih Noyan, Martin Trippler, Julia Pietrek, Jerome Schlue, Michael P Manns, Heiner Wedemeyer, Elmar Jaeckel, Matthias Hardtke-Wolenski

Affiliations

  1. Department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, D-30625 Hannover, Germany.
  2. Department of Gastroenterology and Hepatology, University Hospital Essen, University Duisburg-Essen, D-45147 Essen, Germany.
  3. Institute of Pathology, Hannover Medical School, D-30625 Hannover, Germany.

PMID: 33435354 PMCID: PMC7827897 DOI: 10.3390/biomedicines9010058

Abstract

Autoimmune hepatitis (AIH) is detected at a late stage in the course of the disease. Therefore, induction and etiology are largely unclear. It is controversial if the induction of autoimmunity occurs in the liver or in the spleen. In our experimental murine AIH model, the induction of autoimmunity did not occur in the spleen. Instead, a protective role of the spleen could be more likely. Therefore, we splenectomized mice followed by induction of experimental murine AIH. Splenectomized mice presented more severe portal inflammation. Furthermore, these mice had more IL-17, IL-23 receptor (IL-23R) and caspase 3 (casp3) and a decreased amount of erythropoietin in serum, while intrahepatic T cell compartments were unaffected. These results indicate that the spleen is not necessary for induction of AIH, and splenectomy disrupts the ability to immune regulate the intensity of hepatic inflammation, production of IL-17 and apoptosis.

Keywords: IL-17; adenovirus; apoptosis; autoimmune hepatitis; caspase-3; experimental murine hepatitis; formiminotransferase cyclodeaminase; inflammation; liver; spleen

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