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Pathogens. 2021 Jan 08;10(1). doi: 10.3390/pathogens10010054.

Engineered Phage Endolysin Eliminates .

Pathogens (Basel, Switzerland)

Christine Landlinger, Lenka Tisakova, Vera Oberbauer, Timo Schwebs, Abbas Muhammad, Agnieszka Latka, Leen Van Simaey, Mario Vaneechoutte, Alexander Guschin, Gregory Resch, Sonja Swidsinski, Alexander Swidsinski, Lorenzo Corsini

Affiliations

  1. PhagoMed Biopharma GmbH, Vienna Biocenter, 1110 Wien, Austria.
  2. Laboratory Bacteriology Research, Department of Diagnostic Sciences, Faculty of Medicine & Health Sciences, Ghent University, Flanders, 9000 Gent, Belgium.
  3. Department of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wroclaw, 51-148 Wroclaw, Poland.
  4. Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology Moscow, 119071 Moscow, Russia.
  5. Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland.
  6. MDI Limbach Berlin GmbH, 13407 Berlin, Germany.
  7. Medizinische Klinik, Charité CCM, Humboldt Universität, 10117 Berlin, Germany.
  8. Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.

PMID: 33435575 PMCID: PMC7830407 DOI: 10.3390/pathogens10010054

Abstract

Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome and a characteristic biofilm formed on the vaginal epithelium, which is initiated and dominated by

Keywords: Gardnerella biofilm; alternative to antibiotic treatment; antimicrobial resistance; bacterial vaginosis; endolysin; genus-specificity; prophage

Conflict of interest statement

Conflicts of interest have been declared by the following authors: CL, LT, VO are employees of PhagoMed Biopharma GmbH at the time of the study and LC holds shares in PhagoMed Biopharma GmbH and is th

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