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Cancers (Basel). 2021 Jan 05;13(1). doi: 10.3390/cancers13010153.

Co-Overexpression of TWIST1-CSF1 Is a Common Event in Metastatic Oral Cancer and Drives Biologically Aggressive Phenotype.

Cancers

Sabrina Daniela da Silva, Fabio Albuquerque Marchi, Jie Su, Long Yang, Ludmila Valverde, Jessica Hier, Krikor Bijian, Michael Hier, Alex Mlynarek, Luiz Paulo Kowalski, Moulay A Alaoui-Jamali

Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
  2. Segal Cancer Centre and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Departments of Medicine, Oncology, and Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.
  3. Department of Head and Neck Surgery and Otorhinolaryngology, AC Camargo Cancer Center and National Institute of Science and Technology on Oncogenomics (INCITO), São Paulo 01509-010, Brazil.
  4. School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

PMID: 33466385 PMCID: PMC7795342 DOI: 10.3390/cancers13010153

Abstract

Invasive oral squamous cell carcinoma (OSCC) is often ulcerated and heavily infiltrated by pro-inflammatory cells. We conducted a genome-wide profiling of tissues from OSCC patients (early versus advanced stages) with 10 years follow-up. Co-amplification and co-overexpression of

Keywords: CSF1; EMT; TWIST1; genomic; metastasis; oral squamous cell carcinoma; tumor invasion; tumor-associated macrophages

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