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Materials (Basel). 2021 Jan 05;14(1). doi: 10.3390/ma14010223.

Bio-Absorption of Human Dentin-Derived Biomaterial in Sheep Critical-Size Iliac Defects.

Materials (Basel, Switzerland)

Md Arafat Kabir, Masaru Murata, Mamata Shakya, Katsuhisa Yamada, Toshiyuki Akazawa

Affiliations

  1. Division of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Hokkaido 061-0293, Japan.
  2. Department of Orthopaedic Surgery, Faculty of Medicine and Graduate of Medicine, Hokkaido University, Kita 8 Jonishi 5-chome, Kita-ku, Sapporo, Hokkaido 060-0808, Japan.
  3. Department of Polymer and Ceramics Materials, Industrial Research Institute, Hokkaido Research Organization, Kita 19-jo Nishi 11-chome, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.

PMID: 33466422 PMCID: PMC7796471 DOI: 10.3390/ma14010223

Abstract

The aim of this study was to evaluate the bio-absorption and bone regeneration of human tooth-derived dentin scaffold, entitled as perforated root-demineralized dentin matrix (PR-DDM), after in vivo implantation into the critical-size iliac defects. The dentin scaffolds were prepared from human vital, non-functional teeth. Thirty artificial macro-pores (Ø 1 mm) were added after removing the enamel portion. The modified teeth were supersonically demineralized in 0.34 N HNO

Keywords: bio-absorption; bone regeneration; demineralized dentin matrix; tooth-derived scaffold

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