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Behrendt CA, Kreutzburg T, Kuchenbecker J, et al. Female Sex and Outcomes after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Propensity Score Matched Cohort Analysis. J Clin Med. 2021;10(1)doi: 10.3390/jcm10010162.
Behrendt, C. A., Kreutzburg, T., Kuchenbecker, J., Panuccio, G., Dankhoff, M., Spanos, K., Kouvelos, G., Debus, S., Peters, F., & Kölbel, T. (2021). Female Sex and Outcomes after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Propensity Score Matched Cohort Analysis. Journal of clinical medicine, 10(1), . https://doi.org/10.3390/jcm10010162
Behrendt, Christian-Alexander, et al. "Female Sex and Outcomes after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Propensity Score Matched Cohort Analysis." Journal of clinical medicine vol. 10,1 (2021). doi: https://doi.org/10.3390/jcm10010162
Behrendt CA, Kreutzburg T, Kuchenbecker J, Panuccio G, Dankhoff M, Spanos K, Kouvelos G, Debus S, Peters F, Kölbel T. Female Sex and Outcomes after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Propensity Score Matched Cohort Analysis. J Clin Med. 2021 Jan 05;10(1). doi: 10.3390/jcm10010162. PMID: 33466535; PMCID: PMC7796519.
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J Clin Med. 2021 Jan 05;10(1). doi: 10.3390/jcm10010162.

Female Sex and Outcomes after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Propensity Score Matched Cohort Analysis.

Journal of clinical medicine

Christian-Alexander Behrendt, Thea Kreutzburg, Jenny Kuchenbecker, Giuseppe Panuccio, Mark Dankhoff, Konstantinos Spanos, George Kouvelos, Sebastian Debus, Frederik Peters, Tilo Kölbel

Affiliations

  1. Research Group GermanVasc, Department of Vascular Medicine, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  2. German Aortic Center Hamburg, Department of Vascular Medicine, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  3. DAK-Gesundheit, 22788 Hamburg, Germany.
  4. Department of Vascular Surgery, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.

PMID: 33466535 PMCID: PMC7796519 DOI: 10.3390/jcm10010162

Abstract

OBJECTIVE: Previous studies have showed a potential disadvantage of female patients who underwent abdominal aortic aneurysm (AAA) repair. The current study aims to determine sex-specific perioperative and long-term outcomes using propensity score matched unselected nationwide health insurance claims data.

METHODS: Insurance claims from a large German fund were used, covering around 8% of the insured German population. Patients who underwent endovascular aortic repair (EVAR) for intact AAA from 1 January 2011 to 30 April 2017 were included in the cohort. A 1:2 female to male propensity score matching was applied to adjust for confounding variables. Perioperative and long-term outcomes after 5 years were determined using matching and regression methods.

RESULTS: Among a total of 3736 patients (19.3% females, mean 75 years) undergoing EVAR for intact AAA, we identified 1863 matched patients. Before matching, females were more likely to be previously diagnosed with hypothyroidism, electrolyte disorders, rheumatoid disorders, and depression, while males were more often diabetics. In the matched sample, 23.4% of the females and 25.8% of the males died during a median follow-up of 776 and 792 days, respectively. Perioperatively, females were more likely to exhibit acute limb ischemia (5.3% vs. 3.2%,

CONCLUSION: The current retrospective matched analysis of insurance claims revealed high early access-related morbidity in females when compared to their male counterparts. Short-term or long-term survival and reintervention outcomes were similar between sexes.

Keywords: abdominal aortic aneurysm; endovascular techniques; gender differences; healthcare research; outcome research

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