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Huet F, Fauconnier J, Legall M, et al. Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism. Future Sci OA. 2020;7(2):FSO656doi: 10.2144/fsoa-2020-0151.
Huet, F., Fauconnier, J., Legall, M., Sicard, P., Lozza, C., Lacampagne, A., & Roubille, F. (2020). Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism. Future science OA, 7(2), FSO656. https://doi.org/10.2144/fsoa-2020-0151
Huet, Fabien, et al. "Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism." Future science OA vol. 7,2 (2020): FSO656. doi: https://doi.org/10.2144/fsoa-2020-0151
Huet F, Fauconnier J, Legall M, Sicard P, Lozza C, Lacampagne A, Roubille F. Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism. Future Sci OA. 2020 Nov 23;7(2):FSO656. doi: 10.2144/fsoa-2020-0151. PMID: 33437519; PMCID: PMC7787178.
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Future Sci OA. 2020 Nov 23;7(2):FSO656. doi: 10.2144/fsoa-2020-0151.

Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism.

Future science OA

Fabien Huet, Jérémy Fauconnier, Marion Legall, Pierre Sicard, Catherine Lozza, Alain Lacampagne, François Roubille

Affiliations

  1. Department of Cardiology, Montpellier University Hospital, Montpellier, Occitanie, France.
  2. University of Montpellier, CNRS, INSERM, CHRU Montpellier, Montpellier, France.

PMID: 33437519 PMCID: PMC7787178 DOI: 10.2144/fsoa-2020-0151

Abstract

PURPOSE: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI).

MATERIALS & METHODS: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion.

RESULTS: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70).

CONCLUSION: These results suggest promising protective pathway of colchicine after AMI.

© 2020 Fabien Huet.

Keywords: colchicine; heart rate variability; myocardial infarction; sympathetic innervation

Conflict of interest statement

Financial & competing interests disclosure This work was supported by Inserm, CNRS and Fédération Française de Cardiologie (FFC), and Montpellier University of Montpellier. The authors have no other r

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