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Wondimneh B, Anekere Dasappa Setty S, Gebregzabher Asfeha G, et al. Comparison of Hematological and Biochemical Profile Changes in Pre- and Post-Chemotherapy Treatment of Cancer Patients Attended at Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia 2019: A Retrospective Cohort Study. Cancer Manag Res. 2021;13:625-632doi: 10.2147/CMAR.S274821.
Wondimneh, B., Anekere Dasappa Setty, S., Gebregzabher Asfeha, G., Belay, E., Gebremeskel, G., & Baye, G. (2021). Comparison of Hematological and Biochemical Profile Changes in Pre- and Post-Chemotherapy Treatment of Cancer Patients Attended at Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia 2019: A Retrospective Cohort Study. Cancer management and research, 13625-632. https://doi.org/10.2147/CMAR.S274821
Wondimneh, Bayu, et al. "Comparison of Hematological and Biochemical Profile Changes in Pre- and Post-Chemotherapy Treatment of Cancer Patients Attended at Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia 2019: A Retrospective Cohort Study." Cancer management and research vol. 13 (2021): 625-632. doi: https://doi.org/10.2147/CMAR.S274821
Wondimneh B, Anekere Dasappa Setty S, Gebregzabher Asfeha G, Belay E, Gebremeskel G, Baye G. Comparison of Hematological and Biochemical Profile Changes in Pre- and Post-Chemotherapy Treatment of Cancer Patients Attended at Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia 2019: A Retrospective Cohort Study. Cancer Manag Res. 2021 Jan 22;13:625-632. doi: 10.2147/CMAR.S274821. eCollection 2021. PMID: 33519241; PMCID: PMC7837543.
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Cancer Manag Res. 2021 Jan 22;13:625-632. doi: 10.2147/CMAR.S274821. eCollection 2021.

Comparison of Hematological and Biochemical Profile Changes in Pre- and Post-Chemotherapy Treatment of Cancer Patients Attended at Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia 2019: A Retrospective Cohort Study.

Cancer management and research

Bayu Wondimneh, Sathisha Anekere Dasappa Setty, Gebrekidan Gebregzabher Asfeha, Ezra Belay, Gidey Gebremeskel, Gelagay Baye

Affiliations

  1. Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia.
  2. Departments of Biochemistry and Molecular Biology, Mekelle University, Mekelle, Ethiopia.

PMID: 33519241 PMCID: PMC7837543 DOI: 10.2147/CMAR.S274821

Abstract

PURPOSE: This study aims to compare hematological and biochemical profile changes in pre- and post-chemotherapy among cancer patients admitted at the Oncology Unit of Ayder Comprehensive Specialized Hospital (ACSH), Mekelle, Northern Ethiopia.

PATIENTS AND METHODS: A retrospective cohort study was conducted in 376 cancer patients admitted in the Oncology Unit at ACSH. Demographic data, hematological and biochemical profiles were collected from smart care and patient cards. The data were analyzed using SPSS version 20 statistical package. Descriptive statistics and paired sample students T-test statistical methods were used.

RESULTS: From 376 study subjects, 228 (60.6%) were females. All the hematological profiles, except lymphocyte (LYM) (

CONCLUSION: Hematological profiles, except lymphocytes, were found significantly decreased whereas biochemical profiles, urea, and creatinine were decreased non-significantly, while AST and ALT showed non-significant increments in post-chemotherapy compared to pre-chemotherapy.

© 2021 Wondimneh et al.

Keywords: Ethiopia; biochemical profiles; cancer; chemotherapy; hematological profiles

Conflict of interest statement

The authors report no conflicts of interest for this work.

References

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