Display options
Cite
Niessen WMA. Tandem mass spectrometry of small-molecule antiviral drugs: 1. HIV-related antivirals. Int J Mass Spectrom. 2020;455:116370doi: 10.1016/j.ijms.2020.116370.
Niessen, W. M. A. (2020). Tandem mass spectrometry of small-molecule antiviral drugs: 1. HIV-related antivirals. International journal of mass spectrometry, 455116370. https://doi.org/10.1016/j.ijms.2020.116370
Niessen, W M A. "Tandem mass spectrometry of small-molecule antiviral drugs: 1. HIV-related antivirals." International journal of mass spectrometry vol. 455 (2020): 116370. doi: https://doi.org/10.1016/j.ijms.2020.116370
Niessen WMA. Tandem mass spectrometry of small-molecule antiviral drugs: 1. HIV-related antivirals. Int J Mass Spectrom. 2020 Sep;455:116370. doi: 10.1016/j.ijms.2020.116370. Epub 2020 Jun 15. PMID: 33519296; PMCID: PMC7834215.
Copy Download .nbib Format: NLM
Share it on

Int J Mass Spectrom. 2020 Sep;455:116370. doi: 10.1016/j.ijms.2020.116370. Epub 2020 Jun 15.

Tandem mass spectrometry of small-molecule antiviral drugs: 1. HIV-related antivirals.

International journal of mass spectrometry

W M A Niessen

Affiliations

  1. hyphen MassSpec, Margrietstraat 34, 2215 HJ, Voorhout, the Netherlands.

PMID: 33519296 PMCID: PMC7834215 DOI: 10.1016/j.ijms.2020.116370

Abstract

Antiviral drugs are a class of compounds developed specifically for the treatment of viral infections. In the development and subsequent application of antiviral drugs, like for any other class of drugs, quantitative analysis in biological matrix is important, e.g., to establish bioavailability, to study pharmacokinetics, and later on possibly for therapeutic drug monitoring. Liquid chromatography-mass spectrometry (LC-MS) with tandem mass spectrometry (MS-MS) operated in selected-reaction monitoring (SRM) mode is the method of choice in quantitative bioanalysis. As information of the fragmentation of antiviral drugs in MS-MS is very much scattered in the scientific literature, it was decided to collect this information and to review it, not only to understand which product ions are actually used in SRM, but also to assist in other studies, e.g., in the identification of drug metabolites or (forced) degradation products. In this first study, attention is paid to antiviral agents used against HIV infection. The review provides fragmentation schemes of ca. 40 antiviral agents as well as several phosphorylated anabolites. The identity of the product ions used in SRM, i.e., elemental composition and exact-

© 2020 Elsevier B.V. All rights reserved.

Keywords: Antiviral drugs; CCR5 inhibitors; Fragmentation; HIV; Integrase inhibitors; Non-nucleoside reverse transcriptase inhibitors; Non-peptide protein inhibitors; Nucleoside reverse transcriptase inhibitors; Protein inhibitors; Tandem mass spectrometry

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

  1. J Pharm Biomed Anal. 2020 Jun 5;185:113250 - PubMed
  2. Rapid Commun Mass Spectrom. 2004;18(4):405-11 - PubMed
  3. J Pharm Biomed Anal. 2016 Jan 25;118:214-227 - PubMed
  4. Expert Rev Clin Pharmacol. 2016 Dec;9(12):1583-1595 - PubMed
  5. Chemosphere. 2018 Jun;200:660-670 - PubMed
  6. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3072-82 - PubMed
  7. Drug Metab Dispos. 1997 Jul;25(7):814-27 - PubMed
  8. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 May 25;804(2):359-67 - PubMed
  9. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 1;877(20-21):1805-14 - PubMed
  10. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 15;879(26):2772-82 - PubMed
  11. Rapid Commun Mass Spectrom. 1998;12(22):1756-60 - PubMed
  12. J Sep Sci. 2014 Feb;37(4):368-75 - PubMed
  13. J Am Soc Mass Spectrom. 2014 Dec;25(12):2038-47 - PubMed
  14. Clin Chim Acta. 2014 Apr 20;431:198-205 - PubMed
  15. Drug Metab Dispos. 2003 Mar;31(3):275-81 - PubMed
  16. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 May 25;788(2):377-86 - PubMed
  17. Anal Chem. 2010 Mar 1;82(5):1982-9 - PubMed
  18. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jul 25;821(2):132-43 - PubMed
  19. Bioanalysis. 2013 Feb;5(3):351-68 - PubMed
  20. Anal Bioanal Chem. 2010 Nov;398(6):2573-94 - PubMed
  21. J Pharm Biomed Anal. 2011 Jan 25;54(2):279-85 - PubMed
  22. Biomed Chromatogr. 2013 Feb;27(2):172-8 - PubMed
  23. Rapid Commun Mass Spectrom. 2007;21(15):2505-14 - PubMed
  24. J Pharm Biomed Anal. 2017 Nov 30;146:147-153 - PubMed
  25. Drug Metab Dispos. 2007 Dec;35(12):2186-95 - PubMed
  26. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):82-90 - PubMed
  27. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 1;878(19):1455-65 - PubMed
  28. J Chromatogr A. 2010 Jun 18;1217(25):3908-21 - PubMed
  29. Xenobiotica. 2016;46(2):147-62 - PubMed
  30. Drug Metab Dispos. 2018 May;46(5):493-502 - PubMed
  31. J Chromatogr A. 2010 Aug 20;1217(34):5501-10 - PubMed
  32. J Mass Spectrom. 2013 Jun;48(6):640-50 - PubMed
  33. J Mass Spectrom. 2020 Jun;55(6):e4506 - PubMed
  34. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 15;877(11-12):1057-69 - PubMed
  35. J Pharm Biomed Anal. 2017 May 10;138:223-230 - PubMed
  36. J Mass Spectrom. 2007 Aug;42(8):1024-44 - PubMed
  37. Anal Chem. 2004 Feb 1;76(3):823-32 - PubMed
  38. Clin Biochem. 2016 May;49(7-8):580-6 - PubMed
  39. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 15;867(2):165-71 - PubMed
  40. J Mass Spectrom. 2003 Feb;38(2):157-66 - PubMed
  41. J Pharm Anal. 2015 Apr;5(2):101-109 - PubMed
  42. J Pharm Biomed Anal. 2014 Sep;98:407-16 - PubMed
  43. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 1;878(3-4):466-70 - PubMed
  44. J Pharm Biomed Anal. 2018 Jul 15;156:163-169 - PubMed
  45. Drug Metab Dispos. 1998 Jul;26(7):631-9 - PubMed
  46. J Pharm Biomed Anal. 2000 Jul;22(6):967-83 - PubMed
  47. J Pharm Biomed Anal. 2013 Feb 23;74:101-10 - PubMed
  48. J Pharm Biomed Anal. 2018 Jan 5;147:378-399 - PubMed
  49. Drug Metab Dispos. 2012 Apr;40(4):803-14 - PubMed
  50. J Pharm Biomed Anal. 2011 Nov 1;56(3):637-40 - PubMed
  51. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 15;878(30):3181-6 - PubMed
  52. Bacteriol Rev. 1971 Sep;35(3):235-41 - PubMed
  53. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 1;877(29):3659-66 - PubMed
  54. Biomed Chromatogr. 2009 Apr;23(4):371-81 - PubMed
  55. J Pharm Biomed Anal. 2011 Jun 1;55(3):435-45 - PubMed
  56. Drug Metab Dispos. 2012 Dec;40(12):2221-30 - PubMed
  57. Clin Chim Acta. 2014 Jun 10;433:157-68 - PubMed
  58. J Pharm Biomed Anal. 2013 Dec;86:100-11 - PubMed
  59. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jun 1;868(1-2):1-12 - PubMed
  60. Rapid Commun Mass Spectrom. 2019 Nov 15;33(21):1643-1651 - PubMed
  61. Drug Metab Lett. 2016;10(2):111-23 - PubMed
  62. J Pharm Biomed Anal. 2009 Jan 15;49(1):55-63 - PubMed
  63. Mass Spectrom Rev. 2011 Jul-Aug;30(4):626-63 - PubMed
  64. Rapid Commun Mass Spectrom. 2002;16(6):555-65 - PubMed
  65. Drug Metab Dispos. 2012 Jan;40(1):18-24 - PubMed
  66. J Mass Spectrom. 2013 Jun;48(6):718-31 - PubMed
  67. J Mass Spectrom. 2016 Oct;51(10):959-968 - PubMed
  68. J Pharm Biomed Anal. 2010 Dec 1;53(4):833-42 - PubMed
  69. Int J Mass Spectrom. 2020 Sep;455:116377 - PubMed
  70. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 15;1105:76-84 - PubMed
  71. J Pharm Biomed Anal. 2014 Feb;89:28-33 - PubMed
  72. Drug Metab Dispos. 1997 Jul;25(7):828-39 - PubMed
  73. Rapid Commun Mass Spectrom. 2017 May 15;31(9):771-781 - PubMed
  74. J Chromatogr A. 1998 Jul 3;812(1-2):53-75 - PubMed
  75. Clin Biochem. 2002 Mar;35(2):99-103 - PubMed
  76. Anal Chem. 2012 Oct 16;84(20):8614-21 - PubMed
  77. J Pharm Biomed Anal. 2020 Apr 15;182:113119 - PubMed
  78. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 15;945-946:225-32 - PubMed
  79. Eur J Pharm Sci. 2018 Jul 1;119:70-82 - PubMed
  80. Biomed Chromatogr. 2020 Jan;34(1):e4711 - PubMed
  81. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79 - PubMed
  82. Biomed Chromatogr. 2002 Sep;16(6):383-9 - PubMed
  83. J Pharm Biomed Anal. 2014 Jun;94:92-8 - PubMed
  84. Drug Metab Dispos. 1999 Jan;27(1):86-91 - PubMed
  85. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;1083:209-221 - PubMed
  86. J Pharm Biomed Anal. 2016 Nov 30;131:146-155 - PubMed
  87. Clin Pharmacol Drug Dev. 2019 Jul;8(5):664-673 - PubMed
  88. J Pharm Biomed Anal. 2020 Mar 20;181:113057 - PubMed
  89. Drug Metab Dispos. 2010 May;38(5):871-8 - PubMed
  90. J Pharm Biomed Anal. 2018 Jan 30;148:170-181 - PubMed
  91. J Pharm Biomed Anal. 2016 Nov 30;131:333-344 - PubMed
  92. J Chromatogr A. 2002 Oct 18;974(1-2):91-101 - PubMed
  93. Nurse Pract. 2020 Mar;45(3):28-38 - PubMed
  94. Biochem Pharmacol. 2018 Dec;158:174-184 - PubMed
  95. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 15;975:84-90 - PubMed
  96. Drug Test Anal. 2015 Apr;7(4):290-9 - PubMed
  97. J Mass Spectrom. 2005 Jan;40(1):9-18 - PubMed
  98. Bioanalysis. 2013 Nov;5(22):2771-83 - PubMed
  99. Biomed Chromatogr. 2019 Feb;33(2):e4379 - PubMed
  100. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):310-7 - PubMed
  101. J Am Soc Mass Spectrom. 1999 Feb;10(2):175-83 - PubMed
  102. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 May 25;788(2):339-50 - PubMed
  103. Rapid Commun Mass Spectrom. 2007;21(23):3855-68 - PubMed
  104. J Mass Spectrom. 2008 Feb;43(2):224-33 - PubMed
  105. Ther Drug Monit. 2009 Dec;31(6):695-702 - PubMed

Publication Types