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Calaquian LL, De A. Rifampin-Associated Flu-Like Syndrome in a Patient Undergoing Treatment for a Device-Related Infection. Cureus. 2020;12(12):e12336doi: 10.7759/cureus.12336.
Calaquian, L. L., & De, A. (2020). Rifampin-Associated Flu-Like Syndrome in a Patient Undergoing Treatment for a Device-Related Infection. Cureus, 12(12), e12336. https://doi.org/10.7759/cureus.12336
Calaquian, Loreto L, and De, Asha. "Rifampin-Associated Flu-Like Syndrome in a Patient Undergoing Treatment for a Device-Related Infection." Cureus vol. 12,12 (2020): e12336. doi: https://doi.org/10.7759/cureus.12336
Calaquian LL, De A. Rifampin-Associated Flu-Like Syndrome in a Patient Undergoing Treatment for a Device-Related Infection. Cureus. 2020 Dec 28;12(12):e12336. doi: 10.7759/cureus.12336. PMID: 33520532; PMCID: PMC7837647.
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Cureus. 2020 Dec 28;12(12):e12336. doi: 10.7759/cureus.12336.

Rifampin-Associated Flu-Like Syndrome in a Patient Undergoing Treatment for a Device-Related Infection.

Cureus

Loreto L Calaquian, Asha De

Affiliations

  1. Internal Medicine, Brian D. Allgood Army Community Hospital, Seoul, KOR.
  2. Internal Medicine, San Antonio Military Medical Center, San Antonio, USA.

PMID: 33520532 PMCID: PMC7837647 DOI: 10.7759/cureus.12336

Abstract

Rifampin (or rifampicin) has found extensive use for the treatment of a variety of infectious illnesses, particularly tuberculosis and device-related infections. We describe the development of a flu-like syndrome in a patient undergoing extended antimicrobial therapy with rifampin for discitis and an associated device-related infection, which promptly resolved with discontinuation of rifampin. While the flu-like syndrome has been documented in prior literature covering the treatment of tuberculosis (where the dose regimen tends to be intermittent) there is less evidence for its occurrence in the treatment of device-related infections (which tend to be dosed daily).

Copyright © 2020, Calaquian et al.

Keywords: device-related infection; rifampicin; rifampin; side-effects

Conflict of interest statement

The authors have declared that no competing interests exist.

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