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Lu J, Rosales R, Dampil OA. Comparison of the Efficacy of Levothyroxine Suppression Dose Computed Based on Actual Body Weight vs. Lean Body Mass among Differentiated Thyroid Cancer Patients: A Randomized Controlled Trial. J ASEAN Fed Endocr Soc. 2019;34(2):158-163doi: 10.15605/jafes.034.02.06.
Lu, J., Rosales, R., & Dampil, O. A. (2019). Comparison of the Efficacy of Levothyroxine Suppression Dose Computed Based on Actual Body Weight vs. Lean Body Mass among Differentiated Thyroid Cancer Patients: A Randomized Controlled Trial. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 158-163. https://doi.org/10.15605/jafes.034.02.06
Lu, Johanna, et al. "Comparison of the Efficacy of Levothyroxine Suppression Dose Computed Based on Actual Body Weight vs. Lean Body Mass among Differentiated Thyroid Cancer Patients: A Randomized Controlled Trial." Journal of the ASEAN Federation of Endocrine Societies vol. 34,2 (2019): 158-163. doi: https://doi.org/10.15605/jafes.034.02.06
Lu J, Rosales R, Dampil OA. Comparison of the Efficacy of Levothyroxine Suppression Dose Computed Based on Actual Body Weight vs. Lean Body Mass among Differentiated Thyroid Cancer Patients: A Randomized Controlled Trial. J ASEAN Fed Endocr Soc. 2019;34(2):158-163. doi: 10.15605/jafes.034.02.06. Epub 2019 Nov 10. PMID: 33442151; PMCID: PMC7784150.
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J ASEAN Fed Endocr Soc. 2019;34(2):158-163. doi: 10.15605/jafes.034.02.06. Epub 2019 Nov 10.

Comparison of the Efficacy of Levothyroxine Suppression Dose Computed Based on Actual Body Weight vs. Lean Body Mass among Differentiated Thyroid Cancer Patients: A Randomized Controlled Trial.

Journal of the ASEAN Federation of Endocrine Societies

Johanna Lu, Reynaldo Rosales, Oliver Allan Dampil

Affiliations

  1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, St. Luke's Medical Center, Quezon City, Philippines.

PMID: 33442151 PMCID: PMC7784150 DOI: 10.15605/jafes.034.02.06

Abstract

BACKGROUND: The dose of levothyroxine (LT4) after total thyroidectomy is usually computed based on actual body weight. However, metabolism through deiodination of thyroid hormones usually occur in the lean body compartment. An optimal dose to reduce delay in achieving target levels is essential to improve quality of life, reduce risk factors and cost.

OBJECTIVE: Comparison of the efficacy of two methods of computation for the initial levothyroxine dose in patients with differentiated thyroid cancer based on actual body weight vs. lean body mass in achieving thyroid-stimulating hormone (TSH) goals.

METHODOLOGY: Randomized, single-center, 12-week open label controlled trial among adult patients with differentiated thyroid cancer post total thyroidectomy who underwent radioactive therapy at St. Luke's Medical Center Quezon City from July-December 2018. Participants were divided into 2 groups - Actual Body Weight (ABW) and Lean Body Mass (LBM). Levothyroxine dose was computed based on ABW vs. LBM and TSH determined at 6

RESULTS: 52 participants (ABW n=26; LBM n=26) were included. ABW group had significantly higher mean LT4 dosage (2.2 mcg/kg) compared to the LBM group (1.4 mcg/kg) (

CONCLUSION: Among patients with differentiated thyroid cancer who underwent 1st time RAI therapy, ABW method of computation for LT4 dosage is better compared to the LBM method due to the lower TSH trend seen at 6

© 2019 Journal of the ASEAN Federation of Endocrine Societies.

Keywords: TSH suppression; differentiated thyroid cancer; lean body mass

Conflict of interest statement

The authors declared no conflict of interest.

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