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Dupuis C, Bouadma L, de Montmollin E, et al. Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia. Crit Care Explor. 2021;3(1):e0329doi: 10.1097/CCE.0000000000000329.
Dupuis, C., Bouadma, L., de Montmollin, E., Goldgran-Toledano, D., Schwebel, C., Reignier, J., Neuville, M., Ursino, M., Siami, S., Ruckly, S., Alberti, C., Mourvillier, B., Bailly, S., Grapin, K., Laurent, V., Buetti, N., Gainnier, M., Souweine, B., & Timsit, J. F. (2021). Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia. Critical care explorations, 3(1), e0329. https://doi.org/10.1097/CCE.0000000000000329
Dupuis, Claire, et al. "Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia." Critical care explorations vol. 3,1 (2021): e0329. doi: https://doi.org/10.1097/CCE.0000000000000329
Dupuis C, Bouadma L, de Montmollin E, Goldgran-Toledano D, Schwebel C, Reignier J, Neuville M, Ursino M, Siami S, Ruckly S, Alberti C, Mourvillier B, Bailly S, Grapin K, Laurent V, Buetti N, Gainnier M, Souweine B, Timsit JF. Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia. Crit Care Explor. 2021 Jan 22;3(1):e0329. doi: 10.1097/CCE.0000000000000329. eCollection 2021 Jan. PMID: 33521646; PMCID: PMC7838010.
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Crit Care Explor. 2021 Jan 22;3(1):e0329. doi: 10.1097/CCE.0000000000000329. eCollection 2021 Jan.

Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia.

Critical care explorations

Claire Dupuis, Lila Bouadma, Etienne de Montmollin, Dany Goldgran-Toledano, Carole Schwebel, Jean Reignier, Mathilde Neuville, Moreno Ursino, Shidasp Siami, Stéphane Ruckly, Corinne Alberti, Bruno Mourvillier, Sébastien Bailly, Kévin Grapin, Virginie Laurent, Niccolo Buetti, Marc Gainnier, Bertrand Souweine, Jean-François Timsit

Affiliations

  1. Medical Intensive Care Unit, Gabriel Montpied University Hospital, Clermont-Ferrand, France.
  2. Université de Paris, UMR 1137, IAME, Paris, France.
  3. AP-HP, Medical and Infectious Diseases Intensive Care Unit, Bichat-Claude Bernard Hospital, Paris, France.
  4. Polyvalent ICU, Groupe Hospitalier Intercommunal Le Raincy Montfermeil, Montfermeil, France.
  5. Medical Intensive Care Unit, Grenoble University Hospital, La Tronche, France.
  6. Medical Intensive Care Unit, Nantes University Hospital, Nantes, France.
  7. Polyvalent ICU, Hôpital Foch, Suresnes, France.
  8. F-CRIN PARTNERS Platform, AP-HP, Université de Paris, Paris, France.
  9. Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université de Paris, Paris, France.
  10. Polyvalent ICU, Centre Hospitalier Sud Essonne Dourdan-Etampes, Étampes, France.
  11. Department of Biostatistics, ICUREsearch, Paris, France.
  12. AP-HP, Epidemiology, Hôpital Robert Debré, Paris, France.
  13. Medical Intensive Care Unit, Robert Debré University Hospital, Reims, France.
  14. University Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, Grenoble, France.
  15. Medical-Surgical Intensive Care Unit, André Mignot Hospital, Le Chesnay, France.
  16. AP-HM, Intensive Care Unit, La Timone University Hospital, Marseilles, France.

PMID: 33521646 PMCID: PMC7838010 DOI: 10.1097/CCE.0000000000000329

Abstract

OBJECTIVES: About 5% of patients with coronavirus disease-2019 are admitted to the ICU for acute hypoxemic respiratory failure. Opinions differ on whether invasive mechanical ventilation should be used as first-line therapy over noninvasive oxygen support. The aim of the study was to assess the effect of early invasive mechanical ventilation in coronavirus disease-2019 with acute hypoxemic respiratory failure on day-60 mortality.

DESIGN: Multicenter prospective French observational study.

SETTING: Eleven ICUs of the French OutcomeRea network.

PATIENTS: Coronavirus disease-2019 patients with acute hypoxemic respiratory failure (Pao

INTERVENTION: We compared day-60 mortality in patients who were on invasive mechanical ventilation within the first 2 calendar days of the ICU stay (early invasive mechanical ventilation group) and those who were not (nonearly invasive mechanical ventilation group). We used a Cox proportional-hazard model weighted by inverse probability of early invasive mechanical ventilation to determine the risk of death at day 60.

MEASUREMENT AND MAIN RESULTS: The 245 patients included had a median (interquartile range) age of 61 years (52-69 yr), a Simplified Acute Physiology Score II score of 34 mm Hg (26-44 mm Hg), and a Pao

CONCLUSIONS: In ICU patients admitted with coronavirus disease-2019-induced acute hypoxemic respiratory failure, early invasive mechanical ventilation was associated with an increased risk of day-60 mortality. This result needs to be confirmed.

Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

Keywords: acute hypoxemic respiratory failure; coronavirus disease 2019; critically ill; invasive mechanical ventilation; mortality; noninvasive oxygen support

Conflict of interest statement

Dr. Timsit declares no conflict of interest related to the submitted work. Outside the submitted work, he declares participation in advisory boards for Merck, Pfizer, Gilead, Nabriva, and Paratek, lec

References

  1. Intensive Care Med. 2014 Apr;40(4):582-91 - PubMed
  2. Am J Respir Crit Care Med. 2020 Jul 1;202(1):1-4 - PubMed
  3. Intensive Care Med. 2020 Jun;46(6):1099-1102 - PubMed
  4. JAMA. 2003 Dec 10;290(22):2985-91 - PubMed
  5. Crit Care Med. 1998 Nov;26(11):1793-800 - PubMed
  6. JAMA. 2012 Jun 20;307(23):2526-33 - PubMed
  7. Ann Intern Med. 2020 Aug 4;173(3):204-216 - PubMed
  8. Crit Care. 2013 Nov 11;17(6):R269 - PubMed
  9. Crit Care. 2020 Jul 31;24(1):477 - PubMed
  10. JAMA. 2020 Apr 7;323(13):1239-1242 - PubMed
  11. Crit Care. 2020 Aug 4;24(1):482 - PubMed
  12. JAMA Intern Med. 2014 Oct;174(10):1557 - PubMed
  13. Am J Respir Crit Care Med. 2020 Jun 1;201(11):1319-1320 - PubMed
  14. JAMA Intern Med. 2020 Oct 1;180(10):1345-1355 - PubMed
  15. Crit Care. 2020 Apr 23;24(1):169 - PubMed
  16. Respiration. 2020;99(6):521-542 - PubMed
  17. Cochrane Database Syst Rev. 2014 Apr 29;(4):MR000034 - PubMed
  18. JAMA. 2000 Nov 8;284(18):2361-7 - PubMed
  19. Chest. 1991 Dec;100(6):1619-36 - PubMed
  20. J Epidemiol Community Health. 2006 Jul;60(7):578-86 - PubMed
  21. Intensive Care Med. 2016 Jan;42(1):82-92 - PubMed
  22. Intensive Care Med. 2020 Oct;46(10):1924-1926 - PubMed
  23. Am J Epidemiol. 2008 Sep 15;168(6):656-64 - PubMed
  24. Intensive Care Med. 2020 Oct;46(10):1863-1872 - PubMed
  25. Am J Emerg Med. 2019 Nov;37(11):2091-2096 - PubMed
  26. Stat Methods Med Res. 2016 Oct;25(5):2214-2237 - PubMed
  27. Can J Anaesth. 2020 Sep;67(9):1217-1248 - PubMed
  28. Crit Care Med. 2011 Aug;39(8):1886-95 - PubMed
  29. Am J Respir Crit Care Med. 2019 Jun 1;199(11):1368-1376 - PubMed
  30. JAMA. 2020 Jul 7;324(1):57-67 - PubMed
  31. Eur Respir J. 2020 May 14;55(5): - PubMed
  32. Stat Med. 2006 Jun 30;25(12):2084-106 - PubMed
  33. JAMA. 2015 Oct 27;314(16):1711-9 - PubMed
  34. Intensive Care Med. 2019 May;45(5):563-572 - PubMed
  35. Crit Care Med. 2020 Jun;48(6):e440-e469 - PubMed
  36. PLoS One. 2021 Feb 11;16(2):e0246318 - PubMed
  37. N Engl J Med. 2015 Jun 4;372(23):2185-96 - PubMed
  38. Eur Respir J. 2017 Aug 31;50(2): - PubMed
  39. JAMA. 2020 Jun 9;323(22):2329-2330 - PubMed
  40. JAMA. 2016 May 3;315(17):1902-3 - PubMed
  41. JAMA. 1993 Dec 22-29;270(24):2957-63 - PubMed
  42. Ann Intensive Care. 2020 Jun 9;10(1):78 - PubMed
  43. Crit Care Med. 2020 Nov;48(11):e1045-e1053 - PubMed
  44. Am J Respir Crit Care Med. 2020 Oct 1;202(7):1039-1042 - PubMed
  45. Eur Heart J. 2011 Jul;32(14):1704-8 - PubMed
  46. Intensive Care Med. 2020 Apr;46(4):579-582 - PubMed

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