Display options
Cite
Navarro-Pando JM, Alcocer-Gómez E, Castejón-Vega B, et al. Inhibition of the NLRP3 inflammasome prevents ovarian aging. Sci Adv. 2021;7(1)doi: 10.1126/sciadv.abc7409.
Navarro-Pando, J. M., Alcocer-Gómez, E., Castejón-Vega, B., Navarro-Villarán, E., Condés-Hervás, M., Mundi-Roldan, M., Muntané, J., Pérez-Pulido, A. J., Bullon, P., Wang, C., Hoffman, H. M., Sanz, A., Mbalaviele, G., Ryffel, B., & Cordero, M. D. (2021). Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science advances, 7(1), . https://doi.org/10.1126/sciadv.abc7409
Navarro-Pando, José M, et al. "Inhibition of the NLRP3 inflammasome prevents ovarian aging." Science advances vol. 7,1 (2021). doi: https://doi.org/10.1126/sciadv.abc7409
Navarro-Pando JM, Alcocer-Gómez E, Castejón-Vega B, Navarro-Villarán E, Condés-Hervás M, Mundi-Roldan M, Muntané J, Pérez-Pulido AJ, Bullon P, Wang C, Hoffman HM, Sanz A, Mbalaviele G, Ryffel B, Cordero MD. Inhibition of the NLRP3 inflammasome prevents ovarian aging. Sci Adv. 2021 Jan 01;7(1). doi: 10.1126/sciadv.abc7409. Print 2021 Jan. PMID: 33523841; PMCID: PMC7775749.
Copy Download .nbib Format: NLM
Share it on

Sci Adv. 2021 Jan 01;7(1). doi: 10.1126/sciadv.abc7409. Print 2021 Jan.

Inhibition of the NLRP3 inflammasome prevents ovarian aging.

Science advances

José M Navarro-Pando, Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, Elena Navarro-Villarán, Mónica Condés-Hervás, María Mundi-Roldan, Jordi Muntané, Antonio J Pérez-Pulido, Pedro Bullon, Chun Wang, Hal M Hoffman, Alberto Sanz, Gabriel Mbalaviele, Bernhard Ryffel, Mario D Cordero

Affiliations

  1. Cátedra de Reproducción y Genética Humana del Instituto para el Estudio de la Biología de la Reproducción Humana (INEBIR)-Universidad Europea del Atlántico (UNEATLANTICO)-Fundación Universitaria Iberoamericana (FUNIBER), Seville, Spain.
  2. Departamento de Psicología Experimental, Facultad de Psicología, Universidad de Sevilla, Seville, Spain.
  3. Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, UK.
  4. Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain.
  5. Spanish Network for Biomedical Research in Hepatic and Digestive Diseases (CIBERehd), Carlos III Health Institute (ISCIII), Madrid, Spain.
  6. Department of General Surgery, Hospital University Virgen del Rocío/CSIC/University of Seville/IBIS, Seville, Spain.
  7. Centro Andaluz de Biologia del Desarrollo (CABD, UPO-CSIC-JA), Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, 41013 Seville, Spain.
  8. Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
  9. Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital and University of California San Diego, La Jolla, CA 92093, USA.
  10. Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France.
  11. IDM, University of Cape Town, Cape Town, South Africa.
  12. Cátedra de Reproducción y Genética Humana del Instituto para el Estudio de la Biología de la Reproducción Humana (INEBIR)-Universidad Europea del Atlántico (UNEATLANTICO)-Fundación Universitaria Iberoamericana (FUNIBER), Seville, Spain. [email protected].
  13. Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cadiz, Spain.

PMID: 33523841 PMCID: PMC7775749 DOI: 10.1126/sciadv.abc7409

Abstract

Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

References

  1. Aging Cell. 2020 Mar;19(3):e13102 - PubMed
  2. Am J Reprod Immunol. 2017 May;77(5): - PubMed
  3. Nat Med. 2015 Mar;21(3):248-55 - PubMed
  4. Nucleic Acids Res. 2007;35(22):7466-74 - PubMed
  5. Front Immunol. 2019 Oct 25;10:2538 - PubMed
  6. Cell Mol Life Sci. 2018 Aug;75(15):2777-2792 - PubMed
  7. Cell. 2016 Aug 11;166(4):802-821 - PubMed
  8. Cell Metab. 2013 Oct 1;18(4):519-32 - PubMed
  9. J Immunol Res. 2019 Jan 2;2019:8069898 - PubMed
  10. Endocrinology. 2012 Aug;153(8):3571-8 - PubMed
  11. Mol Endocrinol. 1999 Jun;13(6):841-50 - PubMed
  12. J Immunol. 2014 Jun 1;192(11):5296-304 - PubMed
  13. Antioxid Redox Signal. 2017 Aug 10;27(5):269-275 - PubMed
  14. Hum Reprod. 2011 Jul;26(7):1616-24 - PubMed
  15. Cell. 2011 Sep 2;146(5):682-95 - PubMed
  16. Theriogenology. 2011 Mar 15;75(5):867-76 - PubMed
  17. Science. 2014 Oct 10;346(6206):229-34 - PubMed
  18. Nature. 2006 Mar 9;440(7081):237-41 - PubMed
  19. Nat Med. 2015 Dec;21(12):1416-23 - PubMed
  20. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12492-7 - PubMed
  21. Aging Cell. 2017 Aug;16(4):825-836 - PubMed
  22. Nat Immunol. 2015 Aug;16(8):859-70 - PubMed
  23. Int J Environ Res Public Health. 2020 Feb 24;17(4): - PubMed
  24. J Exp Med. 2018 May 7;215(5):1315-1325 - PubMed
  25. J Immunol. 2019 Nov 15;203(10):2724-2734 - PubMed
  26. J Clin Endocrinol Metab. 1996 Apr;81(4):1495-501 - PubMed
  27. Aging Cell. 2020 Jan;19(1):e13050 - PubMed
  28. J Pineal Res. 2017 Mar;62(2): - PubMed
  29. Sci Rep. 2019 Nov 19;9(1):17097 - PubMed
  30. Nat Immunol. 2017 Jul 19;18(8):861-869 - PubMed
  31. Trends Endocrinol Metab. 2018 Jan;29(1):8-17 - PubMed
  32. Cell. 2020 Feb 6;180(3):585-600.e19 - PubMed
  33. Hum Reprod Update. 2016 Nov;22(6):725-743 - PubMed
  34. Reproduction. 2011 Jun;141(6):759-65 - PubMed
  35. J Cardiovasc Pharmacol. 2014 Apr;63(4):316-322 - PubMed
  36. Antioxid Redox Signal. 2020 Mar 10;32(8):550-568 - PubMed
  37. Nat Commun. 2013;4:2300 - PubMed
  38. Front Immunol. 2018 Jun 04;9:1269 - PubMed
  39. PLoS One. 2012;7(4):e35979 - PubMed
  40. Reprod Med Biol. 2011 Jul 02;10(4):239-249 - PubMed
  41. J Endocrinol Invest. 2020 Jun;43(6):809-820 - PubMed
  42. Biomed Res Int. 2015;2015:625192 - PubMed

Publication Types