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Bandini SB, Spechler JA, Donnelly PE, et al. Perforation Does Not Compromise Patterned Two-Dimensional Substrates for Cell Attachment and Aligned Spreading. ACS Biomater Sci Eng. 2017;3(12):3123-3127doi: 10.1021/acsbiomaterials.7b00339.
Bandini, S. B., Spechler, J. A., Donnelly, P. E., Lim, K., Arnold, C. B., Schwarzbauer, J. E., & Schwartz, J. (2017). Perforation Does Not Compromise Patterned Two-Dimensional Substrates for Cell Attachment and Aligned Spreading. ACS biomaterials science & engineering, 3(12), 3123-3127. https://doi.org/10.1021/acsbiomaterials.7b00339
Bandini, Stephen B, et al. "Perforation Does Not Compromise Patterned Two-Dimensional Substrates for Cell Attachment and Aligned Spreading." ACS biomaterials science & engineering vol. 3,12 (2017): 3123-3127. doi: https://doi.org/10.1021/acsbiomaterials.7b00339
Bandini SB, Spechler JA, Donnelly PE, Lim K, Arnold CB, Schwarzbauer JE, Schwartz J. Perforation Does Not Compromise Patterned Two-Dimensional Substrates for Cell Attachment and Aligned Spreading. ACS Biomater Sci Eng. 2017 Dec 11;3(12):3123-3127. doi: 10.1021/acsbiomaterials.7b00339. Epub 2017 Oct 04. PMID: 33445355.
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ACS Biomater Sci Eng. 2017 Dec 11;3(12):3123-3127. doi: 10.1021/acsbiomaterials.7b00339. Epub 2017 Oct 04.

Perforation Does Not Compromise Patterned Two-Dimensional Substrates for Cell Attachment and Aligned Spreading.

ACS biomaterials science & engineering

Stephen B Bandini, Joshua A Spechler, Patrick E Donnelly, Kelly Lim, Craig B Arnold, Jean E Schwarzbauer, Jeffrey Schwartz

Affiliations

  1. Department of Chemistry, ‡Department of Mechanical and Aerospace Engineering, §Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
  2. Department of Chemistry, Department of Mechanical and Aerospace Engineering, §Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
  3. Department of Chemistry, Department of Mechanical and Aerospace Engineering, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.

PMID: 33445355 DOI: 10.1021/acsbiomaterials.7b00339

Abstract

Polymeric sheets were perforated by laser ablation and were uncompromised by a debris field when first treated with a thin layer of photoresist. Polymer sheets perforated with holes comprising 5, 10, and 20% of the nominal surface area were then patterned in stripes by photolithography, which was followed by synthesis in exposed regions of a cell-attractive zirconium oxide-1,4-butanediphosphonic acid interface. Microscopic and scanning electron microscopy analyses following removal of unexposed photoresist show well-aligned stripes for all levels of these perforations. NIH 3T3 fibroblasts plated on each of these perforated surfaces attached to the interface and spread in alignment with pattern fidelity in every case that is as high as that measured on a nonperforated, patterned substrate.

Keywords: perforated substrate; polymer laser ablation; two-dimensional patterned cell alignment

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