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Horie T, Kijima T, Yamaguchi M, et al. Severe hypoglycaemia under abemaciclib administration in a patient with breast cancer: A case report. Mol Clin Oncol. 2021;14(3):61doi: 10.3892/mco.2021.2223.
Horie, T., Kijima, T., Yamaguchi, M., Honda, S., Horie, M., Ishitobi, K., Yamagata, S., Sakano, S., & Kurokohchi, K. (2021). Severe hypoglycaemia under abemaciclib administration in a patient with breast cancer: A case report. Molecular and clinical oncology, 14(3), 61. https://doi.org/10.3892/mco.2021.2223
Horie, Tatsuo, et al. "Severe hypoglycaemia under abemaciclib administration in a patient with breast cancer: A case report." Molecular and clinical oncology vol. 14,3 (2021): 61. doi: https://doi.org/10.3892/mco.2021.2223
Horie T, Kijima T, Yamaguchi M, Honda S, Horie M, Ishitobi K, Yamagata S, Sakano S, Kurokohchi K. Severe hypoglycaemia under abemaciclib administration in a patient with breast cancer: A case report. Mol Clin Oncol. 2021 Mar;14(3):61. doi: 10.3892/mco.2021.2223. Epub 2021 Jan 25. PMID: 33604051; PMCID: PMC7849062.
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Mol Clin Oncol. 2021 Mar;14(3):61. doi: 10.3892/mco.2021.2223. Epub 2021 Jan 25.

Severe hypoglycaemia under abemaciclib administration in a patient with breast cancer: A case report.

Molecular and clinical oncology

Tatsuo Horie, Tsunetaka Kijima, Minekazu Yamaguchi, Satoshi Honda, Miyako Horie, Kazunari Ishitobi, Shingo Yamagata, Shigeru Sakano, Kazutaka Kurokohchi

Affiliations

  1. Department of Pharmacy, Oda Municipal Hospital, Oda, Shimane 694-0063, Japan.
  2. Department of General Medicine, Shimane University Faculty of Medicine, Oda General Medicine Education Center, Oda, Shimane 694-0063, Japan.
  3. Department of Surgery, Oda Municipal Hospital, Oda, Shimane 694-0063, Japan.
  4. Department of General Medicine, Meiwa Hospital, Nishinomiya, Hyogo 663-8186, Japan.

PMID: 33604051 PMCID: PMC7849062 DOI: 10.3892/mco.2021.2223

Abstract

The current study reports the case of an 80-year-old woman who experienced severe hypoglycaemia after abemaciclib administration, with a recovery time of ~46 h. Abemaciclib is a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor that is used to treat metastatic breast cancer. A side effect of abemaciclib administration is an increase in creatinine levels. The half-life (t

Copyright: © Horie et al.

Keywords: abemaciclib; creatinine; cyclin-dependent kinase 4 and 6; diabetes; protein-binding; renal dysfunction; severe hypoglycaemia

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