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Radzikowska J, Krzeski A, Czarnecka AM, et al. Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma. J Clin Med. 2021;10(3)doi: 10.3390/jcm10030512.
Radzikowska, J., Krzeski, A., Czarnecka, A. M., Klepacka, T., Rychlowska-Pruszynska, M., Raciborska, A., Dembowska-Baginska, B., Pronicki, M., Kukwa, A., Sierdzinski, J., & Kukwa, W. (2021). Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma. Journal of clinical medicine, 10(3), . https://doi.org/10.3390/jcm10030512
Radzikowska, Joanna, et al. "Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma." Journal of clinical medicine vol. 10,3 (2021). doi: https://doi.org/10.3390/jcm10030512
Radzikowska J, Krzeski A, Czarnecka AM, Klepacka T, Rychlowska-Pruszynska M, Raciborska A, Dembowska-Baginska B, Pronicki M, Kukwa A, Sierdzinski J, Kukwa W. Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma. J Clin Med. 2021 Feb 01;10(3). doi: 10.3390/jcm10030512. PMID: 33535525; PMCID: PMC7867094.
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J Clin Med. 2021 Feb 01;10(3). doi: 10.3390/jcm10030512.

Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma.

Journal of clinical medicine

Joanna Radzikowska, Antoni Krzeski, Anna M Czarnecka, Teresa Klepacka, Magdalena Rychlowska-Pruszynska, Anna Raciborska, Bozenna Dembowska-Baginska, Maciej Pronicki, Andrzej Kukwa, Janusz Sierdzinski, Wojciech Kukwa

Affiliations

  1. Department of Otorhinolaryngology, Faculty of Dental Medicine, Medical University of Warsaw, 19/25 Stepinska St., 00-739 Warsaw, Poland.
  2. Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute-Oncology Center, 5 Roentgena St., 02-781 Warsaw, Poland.
  3. Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St., 02-106 Warsaw, Poland.
  4. Department of Pathology, Institute of Mother and Child, 17a Kasprzaka St., 01-211 Warsaw, Poland.
  5. Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, 17a Kasprzaka St., 01-211 Warsaw, Poland.
  6. Department of Pediatric Oncology, The Children's Memorial Health Institute, 20 Dzieci Polskich St., 04-730 Warsaw, Poland.
  7. Department of Pathology, The Children's Memorial Health Institute, 20 Dzieci Polskich St., 04-730 Warsaw, Poland.
  8. Department of Otolaryngology and Head and Neck Diseases, School of Medicine, University of Warmia and Mazury, 30 Warszawska St., 10-082 Olsztyn, Poland.
  9. Department of Medical Informatics and Telemedicine, Medical University of Warsaw, 14/16 Litewska St., 00-581 Warsaw, Poland.

PMID: 33535525 PMCID: PMC7867094 DOI: 10.3390/jcm10030512

Abstract

(1) Background: The study proposed to analyze microvessel density (MVD) in rhabdomyosarcoma (RMS) based on the expression of angiogenesis markers and define its prognostic role in this group of patients. (2) Methods: The study included forty-nine pediatric patients diagnosed with RMS. Tumor tissue expression of CD31, CD34, and CD105 was analyzed. MVD was calculated and correlated with clinical RMS prognostic parameters. (3) Results: CD31, CD34, and CD105 are expressed in all RMS cases. MVD/CD105 was significantly higher in the RMS group than in the control group. The mean and median values of MVD/CD105 in RMS were lower than MVD/CD31 and MVD/CD34. MVD/CD105 was significantly higher in patients with alveolar RMS and those with metastatic disease. Patients with higher levels of MVD/CD105 had a higher risk of death (HR = 1.009). (4) Conclusion: CD105 is a relevant angiogenesis marker in pediatric RMS, and MVD/CD105 is an independent risk factor of short overall survival in children with RMS.

Keywords: endoglin; microvessel density; neoangiogenesis; rhabdomyosarcoma; soft tissue sarcoma

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