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Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1882928.

[No title available]

Gut microbes

Verena Friedrich, Ignasi Forné, Dana Matzek, Diana Ring, Bastian Popper, Lara Jochum, Stefanie Spriewald, Tobias Straub, Axel Imhof, Anne Krug, Bärbel Stecher, Thomas Brocker

Affiliations

  1. Institute for Immunology, BioMedical Center, Faculty of Medicine, LMU Munich , Munich, Germany.
  2. Protein Analysis Unit, BioMedical Center, Faculty of Medicine, LMU Munich , Munich, Germany.
  3. Core Facility Animal Models, BioMedical Center, Faculty of Medicine, LMU Munich , Munich, Germany.
  4. Max von Pettenkofer Institute of Hygiene and Medical Microbiology, LMU Munich , Munich, Germany.
  5. Core Facility Bioinformatics, BioMedical Center, Faculty of Medicine, LMU Munich , Munich, Germany.
  6. German Center for Infection Research (DZIF), Partner Site , Munich, Germany.

PMID: 33550886 PMCID: PMC7889221 DOI: 10.1080/19490976.2021.1882928

Abstract

Gut microbiota and the immune system are in constant exchange shaping both host immunity and microbial communities. Here, improper immune regulation can cause inflammatory bowel disease (IBD) and colitis. Antibody therapies blocking signaling through the CD40-CD40L axis showed promising results as these molecules are deregulated in certain IBD patients. To better understand the mechanism, we used transgenic DC-LMP1/CD40 animals with a constitutive CD40-signal in CD11c

Keywords: Helicobacter hepaticus ; CD103+ DCs; CD40; Colitis; GroEL; iTregs

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