Display options
Cite
Lucock M. Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad. Mol Aspects Med. 2021;100944doi: 10.1016/j.mam.2021.100944.
Lucock, M. (2021). Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad. Molecular aspects of medicine, 100944. https://doi.org/10.1016/j.mam.2021.100944
Lucock, Mark. "Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad." Molecular aspects of medicine vol. (2021): 100944. doi: https://doi.org/10.1016/j.mam.2021.100944
Lucock M. Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad. Mol Aspects Med. 2021 Feb 04;100944. doi: 10.1016/j.mam.2021.100944. Epub 2021 Feb 04. PMID: 33551238.
Copy Download .nbib Format: NLM
Share it on

Mol Aspects Med. 2021 Feb 04;100944. doi: 10.1016/j.mam.2021.100944. Epub 2021 Feb 04.

Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad.

Molecular aspects of medicine

Mark Lucock

Affiliations

  1. School of Environmental & Life Sciences, University of Newcastle, PO Box 127, Brush Rd, Ourimbah, NSW, 2258, Australia. Electronic address: [email protected].

PMID: 33551238 DOI: 10.1016/j.mam.2021.100944

Abstract

The biological role of two key vitamins, folic acid and vitamin D is so fundamental to life processes, it follows that their UV sensitivity, dietary abundance (both key exposomal factors) and variability in dependent genes will modify their functional efficacy, particularly in the context of maintaining the integrity and function of genome and epigenome. This article therefore examines folate and vitamin D-related phenotypic adaptation to environmental factors which vary across the human life cycle as well as over an evolutionary time-scale. Molecular mechanisms, key nutrigenomic factors, phenotypic maladaptation and evolutionary models are discussed.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Adaptation; Epigenetics; Evolution; Exposome; Folic acid; Phenome; Vitamin D

Publication Types