Display options
Cite
Moriya M, Uchida K, Takano S, et al. Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages. Cent Eur J Immunol. 2021;45(4):377-381doi: 10.5114/ceji.2020.103411.
Moriya, M., Uchida, K., Takano, S., Iwase, D., Inoue, G., Muaki, M., Tazawa, R., Aikawa, J., Sekiguchi, H., & Takaso, M. (2020). Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages. Central-European journal of immunology, 45(4), 377-381. https://doi.org/10.5114/ceji.2020.103411
Moriya, Mitsutoshi, et al. "Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages." Central-European journal of immunology vol. 45,4 (2020): 377-381. doi: https://doi.org/10.5114/ceji.2020.103411
Moriya M, Uchida K, Takano S, Iwase D, Inoue G, Muaki M, Tazawa R, Aikawa J, Sekiguchi H, Takaso M. Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages. Cent Eur J Immunol. 2020;45(4):377-381. doi: 10.5114/ceji.2020.103411. Epub 2021 Jan 30. PMID: 33613092; PMCID: PMC7882416.
Copy Download .nbib Format: NLM
Share it on

Cent Eur J Immunol. 2020;45(4):377-381. doi: 10.5114/ceji.2020.103411. Epub 2021 Jan 30.

Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages.

Central-European journal of immunology

Mitsutoshi Moriya, Kentaro Uchida, Shotaro Takano, Dai Iwase, Gen Inoue, Manabu Muaki, Ryo Tazawa, Jun Aikawa, Hiroyuki Sekiguchi, Masashi Takaso

Affiliations

  1. Department of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan.
  2. Shonan University of Medical Sciences Research Institute, Chigasaki City, Kanagawa, Japan.

PMID: 33613092 PMCID: PMC7882416 DOI: 10.5114/ceji.2020.103411

Abstract

Recent evidence suggests that synovial macrophage activation may be involved in cartilage destruction and pain in osteoarthritis (OA). The macrophage-inducible C-type lectin (Mincle) Clec4e is expressed in macrophages and is regulated in inflammatory conditions. Given that the regulation of Mincle in synovial macrophages has not been elucidated, we investigated the expression and regulation of Mincle in human synovial tissue (ST) harvested from patients with radiographic knee OA during total knee arthroplasty. Immunohistochemical and flow cytometric analyses were used to identify cells with Mincle expression in resected tissues. CD14-positive (CD14

Copyright © 2020 Termedia.

Keywords: Mincle; osteoarthritis; synovial tissue; tumor necrosis factor-α

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. J Immunol. 1999 Nov 1;163(9):5039-48 - PubMed
  2. Diabetes. 2011 Mar;60(3):819-26 - PubMed
  3. Osteoarthritis Cartilage. 2010 Oct;18(10):1256-62 - PubMed
  4. Arthritis Res Ther. 2006;8(6):R187 - PubMed
  5. Clin Exp Immunol. 2017 Nov;190(2):235-243 - PubMed
  6. JCI Insight. 2018 Feb 8;3(3): - PubMed
  7. J Biol Chem. 2014 May 30;289(22):15405-12 - PubMed
  8. Ann Rheum Dis. 2006 Apr;65(4):555-6 - PubMed
  9. Kidney Int. 2017 Mar;91(3):587-602 - PubMed
  10. Nat Immunol. 2008 Oct;9(10):1179-88 - PubMed
  11. RMD Open. 2017 Dec 6;3(2):e000527 - PubMed
  12. Front Immunol. 2014 Jun 23;5:288 - PubMed
  13. Kidney Int. 2017 Mar;91(3):526-529 - PubMed
  14. Clin Exp Immunol. 2015 Jun;180(3):551-9 - PubMed
  15. DNA Res. 2006 Aug 31;13(4):169-83 - PubMed
  16. J Immunol. 2012 Sep 15;189(6):3121-9 - PubMed
  17. Int Immunol. 2018 May 24;30(6):233-239 - PubMed
  18. BMC Musculoskelet Disord. 2017 Jul 1;18(1):283 - PubMed

Publication Types